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Targeting Cell Survival Proteins for Cancer Cell DeathBM-1197: a novel and specific Bcl-2/Bcl-xL inhibitor inducing complete and long-lasting tumor regression in vivoAlphaSpace: Fragment-Centric Topographical Mapping To Target Protein-Protein Interaction Interfaces.Cell death and the mitochondria: therapeutic targeting of the BCL-2 family-driven pathway.The mystery of BCL2 family: Bcl-2 proteins and apoptosis: an update.Targeting cancer cell mitochondria as a therapeutic approach: recent updates.Development of 3-phenyl-N-(2-(3-phenylureido)ethyl)-thiophene-2-sulfonamide compounds as inhibitors of antiapoptotic Bcl-2 family proteins.Importance of functional groups in predicting the activity of small molecule inhibitors for Bcl-2 and Bcl-xL.De novo design, synthesis and evaluation of benzylpiperazine derivatives as highly selective binders of Mcl-1.
P2860
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P2860
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 22 March 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A potent and highly efficacious Bcl-2/Bcl-xL inhibitor.
@en
A potent and highly efficacious Bcl-2/Bcl-xL inhibitor.
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type
label
A potent and highly efficacious Bcl-2/Bcl-xL inhibitor.
@en
A potent and highly efficacious Bcl-2/Bcl-xL inhibitor.
@nl
prefLabel
A potent and highly efficacious Bcl-2/Bcl-xL inhibitor.
@en
A potent and highly efficacious Bcl-2/Bcl-xL inhibitor.
@nl
P2093
P2860
P356
P1476
A potent and highly efficacious Bcl-2/Bcl-xL inhibitor.
@en
P2093
Angelo Aguilar
Chao-Yie Yang
Donna McEachern
Haibin Zhou
Jeanne Stuckey
Jennifer Meagher
Jianfang Chen
Longchuan Bai
Shaomeng Wang
P2860
P304
P356
10.1021/JM4001105
P407
P577
2013-03-22T00:00:00Z