about
BH3 mimetics to improve cancer therapy; mechanisms and examplesDesign of Bcl-2 and Bcl-xL Inhibitors with Subnanomolar Binding Affinities Based upon a New ScaffoldProteasomal degradation of Mcl-1 by maritoclax induces apoptosis and enhances the efficacy of ABT-737 in melanoma cellsApoptotic outer hair cell death in the cochleae of aging Fischer 344/NHsd ratsTherapeutic efficacy of ABT-737, a selective inhibitor of BCL-2, in small cell lung cancerApogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteinsNew targets for the treatment of follicular lymphoma.Microarray analysis of serum mRNA in patients with head and neck squamous cell carcinoma at whole-genome scaleRelease of Cytochrome C from Bax Pores at the Mitochondrial Membrane.Genistein inhibits the proliferation and differentiation of MCF-7 and 3T3-L1 cells via the regulation of ERα expression and induction of apoptosisAcquired dependence of acute myeloid leukemia on the DEAD-box RNA helicase DDX5.Potential therapeutic benefits of strategies directed to mitochondria.Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in carcinoma cells.Combined inhibition of Notch signaling and Bcl-2/Bcl-xL results in synergistic antimyeloma effect.Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteinsRadiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival.Simultaneous exposure of transformed cells to SRC family inhibitors and CHK1 inhibitors causes cell death.The mitochondrial death pathway: a promising therapeutic target in diseasesTargeting MCL-1 sensitizes FLT3-ITD-positive leukemias to cytotoxic therapies.MPT0B169, a New Antitubulin Agent, Inhibits Bcr-Abl Expression and Induces Mitochondrion-Mediated Apoptosis in Nonresistant and Imatinib-Resistant Chronic Myeloid Leukemia Cells.Structure-based design of potent Bcl-2/Bcl-xL inhibitors with strong in vivo antitumor activity.Life in the balance: how BH3-only proteins induce apoptosis.Targeting Bcl-2 stability to sensitize cells harboring oncogenic rasTargeting apoptosis with dietary bioactive agents.Cytotoxic effect of ethanol extract of microalga, Chaetoceros calcitrans, and its mechanisms in inducing apoptosis in human breast cancer cell lineSubamolide B Isolated from Medicinal Plant Cinnamomum subavenium Induces Cytotoxicity in Human Cutaneous Squamous Cell Carcinoma Cells through Mitochondrial and CHOP-Dependent Cell Death PathwaysActivating PTPN11 mutants promote hematopoietic progenitor cell-cycle progression and survival.Inhibitory effects of tamoxifen and doxorubicin, alone and in combination, on the proliferation of the MG63 human osteosarcoma cell lineA potent and highly efficacious Bcl-2/Bcl-xL inhibitor.Combined Bcl-2/mammalian target of rapamycin inhibition leads to enhanced radiosensitization via induction of apoptosis and autophagy in non-small cell lung tumor xenograft model.Pseudomonas aeruginosa mannose-sensitive hemagglutinin inhibits proliferation and invasion via the PTEN/AKT pathway in HeLa cells.Antitumor effect and mechanism of an ellagic acid derivative on the HepG2 human hepatocellular carcinoma cell line.Bim upregulation by histone deacetylase inhibitors mediates interactions with the Bcl-2 antagonist ABT-737: evidence for distinct roles for Bcl-2, Bcl-xL, and Mcl-1.R-(-)-gossypol (AT-101) activates programmed cell death in multiple myeloma cells.A phase 1 study of the BCL2-targeted deoxyribonucleic acid inhibitor (DNAi) PNT2258 in patients with advanced solid tumors.Potential Antitumor Effect of Harmine in the Treatment of Thyroid Cancer.Acute myeloid leukemia stem cells: seek and destroy.Delivery systems for in vivo use of nucleic Acid drugs.The role of mitochondria in the development and progression of lung cancerCell type-specific delivery of siRNAs with aptamer-siRNA chimeras.
P2860
Q24655483-84F95598-1AD5-4399-AB53-4581FF3FDA25Q27678209-E285559A-C455-4C91-BB6E-9E15751388E3Q28534817-064DF7BD-FAD0-4D52-AB74-4F09BC94EDD9Q30485601-4F71F9F7-F24B-401F-AFAE-904A7043C3D9Q33326515-D263D08D-459D-4F10-82EC-9E4F099D2A5BQ33431139-3370DF43-12E6-437E-BCFD-074B8F46FF61Q33587396-7FC2D77D-2F05-4CDB-ADAD-A2FADA675F2CQ33597997-F86E504C-FF1B-477E-899D-D1A6DFADB640Q33752784-BF705E38-7C38-439F-BDDF-66144A36F909Q33837460-ED8304CE-DBD3-4B3A-B039-9BB4D3F6A1B9Q33907381-FD48A4AF-49BC-4B95-9A28-122329531B4BQ34117168-405DDA5F-D64F-4B68-95EC-9B9BF603D0E3Q34309934-14E5D7F7-D431-45D8-B82F-B9FBC1F4B468Q34683589-98E60C3F-9892-4631-8B40-5BD009D639E2Q34686567-A9FFDF8A-1877-414F-8C49-0772EEBDD716Q35218738-844C5DE6-CFB1-4C5D-BF50-E7F12B7D7B6BQ35592015-12EE9B88-9661-419B-9391-1A86C6BB390EQ35831981-E550A07E-DCFF-4C8A-9BE6-B20EAF0AC594Q35865681-D2960592-354F-4F2E-B980-EE174506D319Q35905629-A039BEAC-C8B9-4458-B979-678D5509A66DQ36158350-9E3CD98F-DB8C-4616-9B0E-C7A183B6FC92Q36294226-C440A654-5340-4231-BF7D-B22E9CF6D3FBQ36355952-4C5DE512-6C2E-47FC-B0D9-4F5AB5F33D25Q36381878-91495AD7-19F5-4682-B873-8FDB8C9F35E9Q36665143-4D7E7462-A2B0-416B-8210-BBC624257EAAQ36723160-62858609-3877-4CE5-9E3E-821264DED692Q37034852-3ED86B63-ABF2-4495-8539-555F1DB85952Q37229426-46311B82-9B10-4774-BDAF-1A506C6D6EDDQ37249666-5F43331D-3562-4007-AD9C-3CFBCCAD8413Q37373332-E1ADF008-C3DD-4A65-995D-3CCD0EDEEC06Q37392922-BA725B6A-4D2E-4638-A2BC-32D743A5A53DQ37437449-262E175E-F332-4805-AA55-40794FE7C94EQ37451892-42D75D10-A0AE-4EC7-91B8-6D8746DBB553Q37523208-EFA132B4-98CD-4C26-B38A-0A55A3B335CAQ37539213-FA79F7C2-8FC1-40F6-95CA-539EDAA2C5B7Q37657386-031A0294-1BEB-49BD-9AD9-10C0E1DD72BFQ37810086-DA347F21-C4A2-4D02-8423-EC9DD09E98F4Q37928915-639B9B5F-4779-4AC8-A4A2-B3F947CED4C4Q38201044-4B48C4C1-2030-463A-ADA5-0C71C078D119Q38311731-D5F84AF1-CA44-49DB-A0A3-2D51C7D40BBA
P2860
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Killing cancer cells by flipping the Bcl-2/Bax switch.
@ast
Killing cancer cells by flipping the Bcl-2/Bax switch.
@en
type
label
Killing cancer cells by flipping the Bcl-2/Bax switch.
@ast
Killing cancer cells by flipping the Bcl-2/Bax switch.
@en
prefLabel
Killing cancer cells by flipping the Bcl-2/Bax switch.
@ast
Killing cancer cells by flipping the Bcl-2/Bax switch.
@en
P1433
P1476
Killing cancer cells by flipping the Bcl-2/Bax switch
@en
P2093
Jerry M Adams
P356
10.1016/J.CCR.2005.06.012
P577
2005-07-01T00:00:00Z