JAK1 truncating mutations in gynecologic cancer define new role of cancer-associated protein tyrosine kinase aberrations
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The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapesMultilevel genomics of colorectal cancers with microsatellite instability-clinical impact of JAK1 mutations and consensus molecular subtype 1Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions.Inhibition of Shp2 suppresses mutant EGFR-induced lung tumors in transgenic mouse model of lung adenocarcinoma.Local sequence assembly reveals a high-resolution profile of somatic structural variations in 97 cancer genomes.Innate immune defects in HIV permissive cell lines.The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis.Biallelic JAK1 mutations in immunodeficient patient with mycobacterial infection.Sensitization of glycoengineered interferon-β1a-resistant cancer cells by cFLIP inhibition for enhanced anti-cancer therapy.Preclinical Modeling of KIF5B-RET Fusion Lung Adenocarcinoma.Use of the Total Cancer Care System to Enrich Screening for CD30-Positive Solid Tumors for Patient Enrollment Into a Brentuximab Vedotin Clinical Trial: A Pilot Study to Evaluate Feasibility.Endometrial Carcinoma: Specific Targeted Pathways.Microsatellite instability derived JAK1 frameshift mutations are associated with tumor immune evasion in endometrioid endometrial cancer.Overexpression of major CDKN3 transcripts is associated with poor survival in lung adenocarcinomaGenetic defects of the IRF1-mediated major histocompatibility complex class I antigen presentation pathway occur prevalently in the JAK2 gene in non-small cell lung cancer.Loss of function JAK1 mutations occur at high frequency in cancers with microsatellite instability and are suggestive of immune evasion.Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations.Analysis of somatic microsatellite indels identifies driver events in human tumors.Modulation of immunosurveillance by tumor-intrinsic genomic alterations.Next-Generation Sequencing.Complex pattern of immune evasion in MSI colorectal cancer.
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JAK1 truncating mutations in gynecologic cancer define new role of cancer-associated protein tyrosine kinase aberrations
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 24 October 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
JAK1 truncating mutations in g ...... in tyrosine kinase aberrations
@en
JAK1 truncating mutations in g ...... n tyrosine kinase aberrations.
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type
label
JAK1 truncating mutations in g ...... in tyrosine kinase aberrations
@en
JAK1 truncating mutations in g ...... n tyrosine kinase aberrations.
@nl
prefLabel
JAK1 truncating mutations in g ...... in tyrosine kinase aberrations
@en
JAK1 truncating mutations in g ...... n tyrosine kinase aberrations.
@nl
P2093
P2860
P356
P1433
P1476
JAK1 truncating mutations in g ...... in tyrosine kinase aberrations
@en
P2093
David A Fenstermacher
Kenneth L Wright
Richard Z Liu
Yonghong Zhang
P2860
P2888
P356
10.1038/SREP03042
P407
P50
P577
2013-10-24T00:00:00Z