A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIβ.
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The Virus-Host Interplay: Biogenesis of +RNA Replication ComplexesReplication and Inhibitors of Enteroviruses and ParechovirusesUsing hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11Structures of PI4KIII complexes show simultaneous recruitment of Rab11 and its effectorsThe high-resolution crystal structure of phosphatidylinositol 4-kinase IIβ and the crystal structure of phosphatidylinositol 4-kinase IIα containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor designDesign and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβScreening of a Library of FDA-Approved Drugs Identifies Several Enterovirus Replication Inhibitors That Target Viral Protein 2CInvestigation of the Role of Protein Kinase D in Human Rhinovirus ReplicationHuman rhinovirus 16 causes Golgi apparatus fragmentation without blocking protein secretion.New small-molecule inhibitors effectively blocking picornavirus replicationItraconazole inhibits enterovirus replication by targeting the oxysterol-binding proteinModulation of the Host Lipid Landscape to Promote RNA Virus Replication: The Picornavirus Encephalomyocarditis Virus Converges on the Pathway Used by Hepatitis C VirusRecent progress in understanding coxsackievirus replication, dissemination, and pathogenesis.Chinese herbal medicines as a source of molecules with anti-enterovirus 71 activity.Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIα and Oxysterol-Binding ProteinAn siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication.Rewiring of cellular membrane homeostasis by picornaviruses.Fitness and virulence of a coxsackievirus mutant that can circumnavigate the need for phosphatidylinositol 4-kinase class III beta.Recruitment of PI4KIIIβ to coxsackievirus B3 replication organelles is independent of ACBD3, GBF1, and Arf1.Targeting of the hydrophobic metabolome by pathogens.Foot-and-mouth disease virus replicates independently of phosphatidylinositol 4-phosphate and type III phosphatidylinositol 4-kinases.Lipid Tales of Viral Replication and Transmission.Enterovirus 3A facilitates viral replication by promoting PI4KB-ACBD3 interaction.Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα.Phosphatidylinositol 4-kinase III beta is the target of oxoglaucine and pachypodol (Ro 09-0179) for their anti-poliovirus activities, and is located at upstream of the target step of brefeldin A.Cholesterol shuttling is important for RNA replication of coxsackievirus B3 and encephalomyocarditis virus.GBF1- and ACBD3-independent recruitment of PI4KIIIβ to replication sites by rhinovirus 3A proteinsEscaping Host Factor PI4KB Inhibition: Enterovirus Genomic RNA Replication in the Absence of Replication Organelles.
P2860
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P2860
A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIβ.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 29 July 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A novel, broad-spectrum inhibi ...... hatidylinositol 4-kinase IIIβ.
@en
A novel, broad-spectrum inhibi ...... hatidylinositol 4-kinase IIIβ.
@nl
type
label
A novel, broad-spectrum inhibi ...... hatidylinositol 4-kinase IIIβ.
@en
A novel, broad-spectrum inhibi ...... hatidylinositol 4-kinase IIIβ.
@nl
prefLabel
A novel, broad-spectrum inhibi ...... hatidylinositol 4-kinase IIIβ.
@en
A novel, broad-spectrum inhibi ...... hatidylinositol 4-kinase IIIβ.
@nl
P2093
P2860
P50
P356
P1476
A novel, broad-spectrum inhibi ...... hatidylinositol 4-kinase IIIβ.
@en
P2093
Angus M Macleod
Armando de Palma
Dale R Mitchell
Erik Verbeken
Hervé van de Poël
Hilde M van der Schaar
Katja Conrath
Kjerstin H W Lanke
Lonneke van der Linden
Martin Andrews
P2860
P304
P356
10.1128/AAC.01175-13
P407
P577
2013-07-29T00:00:00Z