about
Acute Encephalitis, a Poliomyelitis-like Syndrome and Neurological Sequelae in a Hamster Model for Flavivirus InfectionsA novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase.Interferons, Interferon Inducers, and Interferon-Ribavirin in Treatment of Flavivirus-Induced Encephalitis in MiceThe Imidazopyrrolopyridine Analogue AG110 Is a Novel, Highly Selective Inhibitor of Pestiviruses That Targets the Viral RNA-Dependent RNA Polymerase at a Hot Spot for Inhibition of Viral ReplicationComparative In Vitro Anti-Hepatitis C Virus Activities of a Selected Series of Polymerase, Protease, and Helicase Inhibitors3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects against PicornavirusesA novel benzonitrile analogue inhibits rhinovirus replicationThe RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus familyStructure Elucidation of Coxsackievirus A16 in Complex with GPP3 Informs a Systematic Review of Highly Potent Capsid Binders to EnterovirusesH1PVAT is a novel and potent early-stage inhibitor of poliovirus replication that targets VP1.Identification of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones as novel inhibitors of Chikungunya virus replication.Discovery of a novel HCV helicase inhibitor by a de novo drug design approach.Coumarin-purine ribofuranoside conjugates as new agents against hepatitis C virus.Efficacy of cidofovir in a murine model of disseminated progressive vaccinia.New pyrazolobenzothiazine derivatives as hepatitis C virus NS5B polymerase palm site I inhibitors.The anti-yellow fever virus activity of ribavirin is independent of error-prone replication.Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication.The capsid binder Vapendavir and the novel protease inhibitor SG85 inhibit enterovirus 71 replication.Structure-activity relationship study of arbidol derivatives as inhibitors of chikungunya virus replication.Bioengineering and semisynthesis of an optimized cyclophilin inhibitor for treatment of chronic viral infection.Synthesis of novel purine-based coxsackievirus inhibitors bearing polycylic substituents at the N-9 position.Synergy of entry inhibitors with direct-acting antivirals uncovers novel combinations for prevention and treatment of hepatitis C.Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding proteinRodent models for the study of therapy against flavivirus infections.Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication.Shape-based virtual screening, synthesis and evaluation of novel pyrrolone derivatives as antiviral agents against HCV.Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases.Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68.Selective serotonin reuptake inhibitor fluoxetine inhibits replication of human enteroviruses B and D by targeting viral protein 2C.Phosphatidylinositol 4-kinase III beta is essential for replication of human rhinovirus and its inhibition causes a lethal phenotype in vivo.Simplified Bryostatin Analogues Protect Cells from Chikungunya Virus-Induced Cell Death.Inhibition of Chikungunya Virus-Induced Cell Death by Salicylate-Derived Bryostatin Analogues Provides Additional Evidence for a PKC-Independent Pathway.Molecular strategies to inhibit the replication of RNA viruses.A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIβ.The versatile nature of the 6-aminoquinolone scaffold: identification of submicromolar hepatitis C virus NS5B inhibitors.Fitness and virulence of a coxsackievirus mutant that can circumnavigate the need for phosphatidylinositol 4-kinase class III beta.Antiviral activity of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones against chikungunya virus targeting the viral capping nsP1.In silico identification, design and synthesis of novel piperazine-based antiviral agents targeting the hepatitis C virus helicase.Comparative analysis of the anti-chikungunya virus activity of novel bryostatin analogs confirms the existence of a PKC-independent mechanism.Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Pieter Leyssen
@ast
Pieter Leyssen
@en
Pieter Leyssen
@es
Pieter Leyssen
@nl
Pieter Leyssen
@sl
type
label
Pieter Leyssen
@ast
Pieter Leyssen
@en
Pieter Leyssen
@es
Pieter Leyssen
@nl
Pieter Leyssen
@sl
prefLabel
Pieter Leyssen
@ast
Pieter Leyssen
@en
Pieter Leyssen
@es
Pieter Leyssen
@nl
Pieter Leyssen
@sl