Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled. - Wikidata - awgldk - TriplyDB

Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled.

Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled.

http://www.wikidata.org/entity/Q37269189

about

Wnt/beta-catenin signaling and small molecule inhibitors Wnt Signaling in Cancer Stem Cell Biology Development of anticancer agents targeting the Wnt/β-catenin signaling Flavonoids and Wnt/β-catenin signaling: potential role in colorectal cancer therapies Targeting the Wnt pathway in human cancers: therapeutic targeting with a focus on OMP-54F28 Role of PDZ proteins in regulating trafficking, signaling, and function of GPCRs: means, motif, and opportunity A Genome-Wide RNA Interference Screen Identifies a Role for Wnt/β-Catenin Signaling during Rift Valley Fever Virus Infection Sulindac Inhibits Canonical Wnt Signaling by Blocking the PDZ Domain of the Protein Dishevelled Discovery, structure-activity relationship studies, and crystal structure of nonpeptide inhibitors bound to the Shank3 PDZ domain Stereochemical Determinants of C-terminal Specificity in PDZ Peptide-binding Domains: A NOVEL CONTRIBUTION OF THE CARBOXYLATE-BINDING LOOP Wnt Drug Discovery: Weaving Through the Screens, Patents and Clinical Trials Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein Wnt/β-catenin signalling in prostate cancer An in silico analysis of the binding modes and binding affinities of small molecule modulators of PDZ-peptide interactions Accidental interaction between PDZ domains and diclofenac revealed by NMR-assisted virtual screening.Prostate cancer progression and metastasis: potential regulatory pathways for therapeutic targeting.Functional regulation of cystic fibrosis transmembrane conductance regulator-containing macromolecular complexes: a small-molecule inhibitor approach WNT-pathway components as predictive markers useful for diagnosis, prevention and therapy in inflammatory bowel disease and sporadic colorectal cancer.Development of small molecules targeting the Wnt pathway for the treatment of colon cancer: a high-throughput screening approach.Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1 Gonad RNA-specific qRT-PCR analyses identify genes with potential functions in schistosome reproduction such as SmFz1 and SmFGFRs.Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling.Small molecule modulators of Wnt/β-catenin signaling.The Wnt signaling pathway: implications for therapy in osteosarcoma.Computational design of selective peptides to discriminate between similar PDZ domains in an oncogenic pathway Functional inhibition of β-catenin-mediated Wnt signaling by intracellular VHH antibodies Can we safely target the WNT pathway?Protein purification using PDZ affinity chromatography.Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics.Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update Conformational change of Dishevelled plays a key regulatory role in the Wnt signaling pathways WNT10B enhances proliferation through β-catenin and RAC1 GTPase in human corneal endothelial cells The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies MicroRNA-24 Attenuates Neointimal Hyperplasia in the Diabetic Rat Carotid Artery Injury Model by Inhibiting Wnt4 Signaling Pathway PDZ domains and viral infection: versatile potentials of HPV-PDZ interactions in relation to malignancy On target? Strategies and progress in the development of therapies for colorectal cancer targeted against WNT signalling.Virtual ligand screening combined with NMR to identify Dvl PDZ domain inhibitors targeting the Wnt signaling.A novel non-canonical Wnt signature for prostate cancer aggressiveness.Drug discovery approaches to target Wnt signaling in cancer stem cells.PDZ domains: the building blocks regulating tumorigenesis.

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P2860

Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled.

http://www.wikidata.org/entity/Q37269189

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 21 April 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Discovery and characterization ...... the PDZ domain of dishevelled.

@en

Discovery and characterization ...... the PDZ domain of dishevelled.

@nl

type

label

Discovery and characterization ...... the PDZ domain of dishevelled.

@en

Discovery and characterization ...... the PDZ domain of dishevelled.

@nl

prefLabel

Discovery and characterization ...... the PDZ domain of dishevelled.

@en

Discovery and characterization ...... the PDZ domain of dishevelled.

@nl

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JBC.M109.009647

P1433

Journal of Biological Chemistry

P1476

Discovery and characterization ...... the PDZ domain of dishevelled

@en

P2093

David Grandy

http://www.w3.org/2001/XMLSchema#string

De-Li Shi

http://www.w3.org/2001/XMLSchema#string

Hongyan Li

http://www.w3.org/2001/XMLSchema#string

Ivan Alpatov

http://www.w3.org/2001/XMLSchema#string

Jufang Shan

http://www.w3.org/2001/XMLSchema#string

Richard A Lang

http://www.w3.org/2001/XMLSchema#string

Shailaja Akunuru

http://www.w3.org/2001/XMLSchema#string

Sujata Rao

http://www.w3.org/2001/XMLSchema#string

Xin A Zhang

http://www.w3.org/2001/XMLSchema#string

Xinxin Zhang

http://www.w3.org/2001/XMLSchema#string

P2860

A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus

Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway

Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains

Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation

Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

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P304

16256-16263

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scholarly article

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10.1074/JBC.M109.009647

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P407

P433

24

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P478

284

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2009-04-21T00:00:00Z

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19383605

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2713547

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