Knockout mouse models for intestinal electrolyte transporters and regulatory PDZ adaptors: new insights into cystic fibrosis, secretory diarrhoea and fructose-induced hypertension.
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In Vitro and in Vivo Analysis of the Binding of the C Terminus of the HDL Receptor Scavenger Receptor Class B, Type I (SR-BI), to the PDZ1 Domain of Its Adaptor Protein PDZK1IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathwayFrequency of rare allelic variation in candidate genes among individuals with low and high urinary calcium excretionRole of the adaptor protein PDZK1 in controlling the HDL receptor SR-BIThe switch of intestinal Slc26 exchangers from anion absorptive to HCOFormula secretory mode is dependent on CFTR anion channel function.The ethanol-induced stimulation of rat duodenal mucosal bicarbonate secretion in vivo is critically dependent on luminal Cl-NHERF2/NHERF3 protein heterodimerization and macrocomplex formation are required for the inhibition of NHE3 activity by carbachol.Downregulation of the NHE3-binding PDZ-adaptor protein PDZK1 expression during cytokine-induced inflammation in interleukin-10-deficient mice.Binding to Na(+) /H(+) exchanger regulatory factor 2 (NHERF2) affects trafficking and function of the enteropathogenic Escherichia coli type III secretion system effectors Map, EspI and NleH.NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activity.Role of PDZK1 protein in apical membrane expression of renal sodium-coupled phosphate transporters.Phosphorylation of ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) by Akt promotes stability and mitogenic function of S-phase kinase-associated protein-2 (Skp2).Alterations in the proteome of the NHERF2 knockout mouse jejunal brush border membrane vesicles.The scaffolding protein EBP50 promotes vascular smooth muscle cell proliferation and neointima formation by regulating Skp2 and p21(cip1).CFTR-SLC26 transporter interactions in epithelia.Intestinal smooth muscle dysfunction develops postnatally in cystic fibrosis miceThe cystic fibrosis intestine.Rescue of epithelial HCO3- secretion in murine intestine by apical membrane expression of the cystic fibrosis transmembrane conductance regulator mutant F508del.Novel Insight Into the Role of CFTR in Lacrimal Gland Duct Function in Mice.
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P2860
Knockout mouse models for intestinal electrolyte transporters and regulatory PDZ adaptors: new insights into cystic fibrosis, secretory diarrhoea and fructose-induced hypertension.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 17 October 2008
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Knockout mouse models for inte ...... fructose-induced hypertension.
@en
Knockout mouse models for inte ...... fructose-induced hypertension.
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type
label
Knockout mouse models for inte ...... fructose-induced hypertension.
@en
Knockout mouse models for inte ...... fructose-induced hypertension.
@nl
prefLabel
Knockout mouse models for inte ...... fructose-induced hypertension.
@en
Knockout mouse models for inte ...... fructose-induced hypertension.
@nl
P2093
P2860
P921
P1476
Knockout mouse models for inte ...... fructose-induced hypertension
@en
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Anurag Singh
Ayhan Cinar
Brigitte Riederer
Mingmin Chen
Sunil Yeruva
Ursula Seidler
P2860
P304
P356
10.1113/EXPPHYSIOL.2008.043018
P577
2008-10-17T00:00:00Z