Prevention and treatment of experimental estrogen receptor-negative mammary carcinogenesis by the synthetic triterpenoid CDDO-methyl Ester and the rexinoid LG100268.
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Preclinical evidences toward the use of triterpenoid CDDO-Me for solid cancer prevention and treatmentNew synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stressCDDO-Me protects normal lung and breast epithelial cells but not cancer cells from radiationChemopreventive effect of a novel oleanane triterpenoid in a chemically induced rodent model of breast cancerPotency ranking of triterpenoids as inducers of a cytoprotective enzyme and as inhibitors of a cellular inflammatory response via their electron affinity and their electrophilicity index.Triterpenoids CDDO-methyl ester or CDDO-ethyl amide and rexinoids LG100268 or NRX194204 for prevention and treatment of lung cancer in mice.Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer.Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis.Proteomic analysis shows synthetic oleanane triterpenoid binds to mTORAn exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas.Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer.Breaking the NF-κB and STAT3 alliance inhibits inflammation and pancreatic tumorigenesis.Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties.Oleanane triterpenoids in the prevention and therapy of breast cancer: current evidence and future perspectives.Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer.Bardoxolone methyl induces apoptosis and autophagy and inhibits epithelial-to-mesenchymal transition and stemness in esophageal squamous cancer cells.CDDO-methyl ester delays breast cancer development in BRCA1-mutated mice.Metabolism and regulation of gene expression by 4-oxoretinol versus all-trans retinoic acid in normal human mammary epithelial cells.Morinda citrifolia (Noni) Juice Augments Mammary Gland Differentiation and Reduces Mammary Tumor Growth in Mice Expressing the Unactivated c-erbB2 Transgene.Targeting HER2 Positive Breast Cancer with Chemopreventive Agents.Chemoprevention of hormone receptor-negative breast cancer: new approaches neededSynthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease.Ca2+ influx-mediated dilation of the endoplasmic reticulum and c-FLIPL downregulation trigger CDDO-Me-induced apoptosis in breast cancer cellsThe combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancerRetinoid X receptor and peroxisome proliferator-activated receptor-gamma agonists cooperate to inhibit matrix metalloproteinase gene expression.Targeting nrf2-mediated gene transcription by triterpenoids and their derivatives.Oral administration of a gemini vitamin D analog, a synthetic triterpenoid and the combination prevents mammary tumorigenesis driven by ErbB2 overexpression.Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.Oleanolic acid and its synthetic derivatives for the prevention and therapy of cancer: preclinical and clinical evidence.The cytoprotective role of the Keap1-Nrf2 pathway.Design of small molecules targeting transcriptional activation by NF-κB: overview of recent advances.Advances in Preventive Therapy for Estrogen-Receptor-Negative Breast Cancer.Preventive effects of bexarotene and budesonide in a genetically engineered mouse model of small cell lung cancer.Nrf2-Dependent and -Independent Effects of tert-Butylhydroquinone, CDDO-Im, and H2O2 in Human Jurkat T Cells as Determined by CRISPR/Cas9 Gene Editing.The synthetic triterpenoid CDDO-Imidazolide suppresses experimental liver metastasis.
P2860
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P2860
Prevention and treatment of experimental estrogen receptor-negative mammary carcinogenesis by the synthetic triterpenoid CDDO-methyl Ester and the rexinoid LG100268.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Prevention and treatment of ex ...... ter and the rexinoid LG100268.
@en
Prevention and treatment of ex ...... ter and the rexinoid LG100268.
@nl
type
label
Prevention and treatment of ex ...... ter and the rexinoid LG100268.
@en
Prevention and treatment of ex ...... ter and the rexinoid LG100268.
@nl
prefLabel
Prevention and treatment of ex ...... ter and the rexinoid LG100268.
@en
Prevention and treatment of ex ...... ter and the rexinoid LG100268.
@nl
P2093
P2860
P1476
Prevention and treatment of ex ...... ter and the rexinoid LG100268.
@en
P2093
Charlotte R Williams
Darlene B Royce
Gordon W Gribble
Ilaria Sogno
Mark M Yore
Michael B Sporn
Nicola Vannini
Renee Risingsong
Tadashi Honda
William W Lamph
P2860
P304
P356
10.1158/1078-0432.CCR-08-0040
P407
P577
2008-07-01T00:00:00Z