Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice. - Wikidata - awgldk - TriplyDB

Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.

Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.

http://www.wikidata.org/entity/Q37214176

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Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2 A diet rich in high-glucoraphanin broccoli interacts with genotype to reduce discordance in plasma metabolite profiles by modulating mitochondrial function The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism Interplay between cytosolic disulfide reductase systems and the Nrf2/Keap1 pathway A perspective on dietary phytochemicals and cancer chemoprevention: oxidative stress, nrf2, and epigenomics Emerging roles of Nrf2 signal in non-small cell lung cancer When NRF2 talks, who's listening?Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders The complexity of the Nrf2 pathway: beyond the antioxidant response Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders Glucose availability is a decisive factor for Nrf2-mediated gene expression Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium The transcriptional response to oxidative stress during vertebrate development: effects of tert-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin Nrf2: friend or foe for chemoprevention?Low-Dose Dose-Response for In Vitro Nrf2-ARE Activation in Human HepG2 Cells Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy.Aggressive mammary carcinoma progression in Nrf2 knockout mice treated with 7,12-dimethylbenz[a]anthracene.Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver.Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications Proteomic analysis shows synthetic oleanane triterpenoid binds to mTOR Sulforaphane protects Microcystin-LR-induced toxicity through activation of the Nrf2-mediated defensive response NRF2 and cancer: the good, the bad and the importance of context.Visualization of the Drosophila dKeap1-CncC interaction on chromatin illumines cooperative, xenobiotic-specific gene activation.Nrf2 affects the efficiency of mitochondrial fatty acid oxidation.Frugal chemoprevention: targeting Nrf2 with foods rich in sulforaphane Redox-based therapeutics in neurodegenerative disease.Genetic activation of Nrf2 protects against fasting-induced oxidative stress in livers of mice.The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation.Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARγ, and HO-1.Targeting NRF2 signaling for cancer chemoprevention.Keap1-knockdown decreases fasting-induced fatty liver via altered lipid metabolism and decreased fatty acid mobilization from adipose tissue Nrf2 represses FGF21 during long-term high-fat diet-induced obesity in mice.Oral azathioprine leads to higher incorporation of 6-thioguanine in DNA of skin than liver: the protective role of the Keap1/Nrf2/ARE pathway.RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity.Cancer Cell Growth Is Differentially Affected by Constitutive Activation of NRF2 by KEAP1 Deletion and Pharmacological Activation of NRF2 by the Synthetic Triterpenoid, RTA 405.Formation and signaling actions of electrophilic lipids Effects of Silicon vs. Hydroxytyrosol-Enriched Restructured Pork on Liver Oxidation Status of Aged Rats Fed High-Saturated/High-Cholesterol Diets.

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Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.

http://www.wikidata.org/entity/Q37214176

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 21 April 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Genetic versus chemoprotective ...... and triterpenoid-treated mice.

@en

Genetic versus chemoprotective ...... and triterpenoid-treated mice.

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type

label

Genetic versus chemoprotective ...... and triterpenoid-treated mice.

@en

Genetic versus chemoprotective ...... and triterpenoid-treated mice.

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prefLabel

Genetic versus chemoprotective ...... and triterpenoid-treated mice.

@en

Genetic versus chemoprotective ...... and triterpenoid-treated mice.

@nl

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Genetic versus chemoprotective ...... and triterpenoid-treated mice

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Charlotte R Williams

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Colin C McCulloch

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Jay B Silkworth

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Keiko Taguchi

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Masayuki Yamamoto

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Melinda S Yates

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Michael B Sporn

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Patrick M Dolan

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Quynh T Tran

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Soona Shin

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P2860

Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors.

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

The in vivo gene expression signature of oxidative stress

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults

Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Nrf2-Keap1 defines a physiologically important stress response mechanism

Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

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1024-1031

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10.1093/CARCIN/BGP100

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6

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30

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2009-04-21T00:00:00Z

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24349909

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19386581

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2691141

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