Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment.
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Valine 1532 of human BRC repeat 4 plays an important role in the interaction between BRCA2 and RAD51MERIT40 facilitates BRCA1 localization and DNA damage repairEvidence that BRCA1- or BRCA2-associated cancers are not inevitableInterplay between Fanconi anemia and homologous recombination pathways in genome integrityThe expanding role of yeast in cancer research and diagnosis: insights into the function of the oncosuppressors p53 and BRCA1/2Using a Fragment-Based Approach To Target Protein-Protein InteractionsRANKL/RANK: from bone loss to the prevention of breast cancerBRCA2 acts as a RAD51 loader to facilitate telomere replication and cappingUnraveling the mechanism of BRCA2 in homologous recombinationTumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombinationBRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progenyA genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenanceEffect of the BRCA2 CTRD domain on RAD51 filaments analyzed by an ensemble of single molecule techniques.Overexpression of RAD51 suppresses recombination defects: a possible mechanism to reverse genomic instability.Gross genomic alterations and gene expression profiles of high- grade serous carcinoma of the ovary with and without BRCA1 inactivation.Cell cycle-dependent regulation of the bi-directional overlapping promoter of human BRCA2/ZAR2 genes in breast cancer cells.Assessment of changes in the BRCA2 and P53 genes in breast invasive ductal carcinoma in northeast Brazil.Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease.Cancer models in Caenorhabditis elegans.Influence of homologous recombinational repair on cell survival and chromosomal aberration induction during the cell cycle in gamma-irradiated CHO cellsPTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors.The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination.DNA repair and personalized breast cancer therapyBRCA1-directed, enhanced and aberrant homologous recombination: mechanism and potential treatment strategies.Genome-wide analysis reveals a role for BRCA1 and PALB2 in transcriptional co-activationCancer suppression by the chromosome custodians, BRCA1 and BRCA2.Effects of the missense mutations in canine BRCA2 on BRC repeat 3 functions and comparative analyses between canine and human BRC repeat 3A functional TNFAIP2 3'-UTR rs8126 genetic polymorphism contributes to risk of esophageal squamous cell carcinoma.Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wild type breast cancer cells.ATM suppresses SATB1-induced malignant progression in breast epithelial cellsSynthetic viability by BRCA2 and PARP1/ARTD1 deficiencies.Clinical application of micronucleus test: a case-control study on the prediction of breast cancer risk/susceptibilitySkp2 overexpression is associated with loss of BRCA2 protein in human prostate cancer.MYC and Breast Cancer.Ligand-dependent differences in estrogen receptor beta-interacting proteins identified in lung adenocarcinoma cells corresponds to estrogenic responses.Small-molecule inhibitors that target protein-protein interactions in the RAD51 family of recombinasesDNA repair mechanisms in cancer development and therapyHomologous recombination repair is essential for repair of vosaroxin-induced DNA double-strand breaks.Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility.
P2860
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P2860
Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
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name
Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment.
@en
Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment.
@nl
type
label
Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment.
@en
Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment.
@nl
prefLabel
Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment.
@en
Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment.
@nl
P1476
Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment.
@en
P2093
Ashok R Venkitaraman
P304
P356
10.1146/ANNUREV.PATHOL.3.121806.151422
P577
2009-01-01T00:00:00Z