Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination - Wikidata - awgldk - TriplyDB

Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination

Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination

http://www.wikidata.org/entity/Q28294199

about

ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair Breast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forks Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair Interactions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantum The Knowns Unknowns: Exploring the Homologous Recombination Repair Pathway in Toxoplasma gondii Role of Biomarkers in the Development of PARP Inhibitors DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2 DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer Use of poly ADP-ribose polymerase [PARP] inhibitors in cancer cells bearing DDR defects: the rationale for their inclusion in the clinic Predictors and Modulators of Synthetic Lethality: An Update on PARP Inhibitors and Personalized Medicine Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins Molding BRCA2 function through its interacting partners NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell-based assay Unraveling the mechanism of BRCA2 in homologous recombination PALB2: the hub of a network of tumor suppressors involved in DNA damage responses Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer RecO protein initiates DNA recombination and strand annealing through two alternative DNA binding mechanisms.A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance Cancer-causing mutations in the tumor suppressor PALB2 reveal a novel cancer mechanism using a hidden nuclear export signal in the WD40 repeat motif Strategies for the Use of Poly(adenosine diphosphate ribose) Polymerase (PARP) Inhibitors in Cancer Therapy.Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery.Male fertility defect associated with disrupted BRCA1-PALB2 interaction in mice Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains.Mutation analysis of PALB2 in BRCA1 and BRCA2-negative breast and/or ovarian cancer families from Eastern Ontario, Canada.Rad51 regulates cell cycle progression by preserving G2/M transition in mouse embryonic stem cells.Structure and mechanism of action of the BRCA2 breast cancer tumor suppressor BRCA1 promoter hypermethylation, 53BP1 protein expression and PARP-1 activity as biomarkers of DNA repair deficit in breast cancer Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability EgoNet: identification of human disease ego-network modules S100A11 plays a role in homologous recombination and genome maintenance by influencing the persistence of RAD51 in DNA repair foci.Requirement of heterogeneous nuclear ribonucleoprotein C for BRCA gene expression and homologous recombination.Evaluation of the need for routine clinical testing of PALB2 c.1592delT mutation in BRCA negative Northern Finnish breast cancer families Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer.Synthetic lethality of PARP inhibition in cancers lacking BRCA1 and BRCA2 mutations.Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase.Roles of Rad51 paralogs for promoting homologous recombination in Leishmania infantum.Dual DNA-binding domains shape the interaction of Brh2 with DNA.The ups and downs of DNA repair biomarkers for PARP inhibitor therapies

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Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination

http://www.wikidata.org/entity/Q28294199

description

2010 nî lūn-bûn

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2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Cooperation of breast cancer p ...... ating homologous recombination

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Cooperation of breast cancer p ...... ating homologous recombination

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Cooperation of breast cancer p ...... ating homologous recombination

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Cooperation of breast cancer p ...... ating homologous recombination

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Cooperation of breast cancer p ...... ating homologous recombination

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Cooperation of breast cancer p ...... ating homologous recombination

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Cooperation of breast cancer p ...... ating homologous recombination

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Cooperation of breast cancer p ...... ating homologous recombination

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Cooperation of breast cancer p ...... ating homologous recombination

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P1433

Nature Structural & Molecular Biology

P1476

Cooperation of breast cancer p ...... ating homologous recombination

@en

P2093

Alicja Z Stasiak

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Andrzej Stasiak

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Anne-Marie Dion-Côté

http://www.w3.org/2001/XMLSchema#string

Bing Xia

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Hong Cai

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Hélène Launay

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Jean-Yves Masson

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Rémi Buisson

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Yan Coulombe

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P2860

CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

Interplay between human DNA repair proteins at a unique double-strand break in vivo

Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2.

Structural basis for recruitment of BRCA2 by PALB2

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

Insights into DNA recombination from the structure of a RAD51-BRCA2 complex

PALB2 regulates recombinational repair through chromatin association and oligomerization

The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

Human CtIP promotes DNA end resection

P2888

P304

1247-54

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scholarly article

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1761655

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10.1038/NSMB.1915

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P433

10

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17

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2010-10-01T00:00:00Z

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46427984

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20871615

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structural biology

P932

4094107

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