Retina-specific GTPase accelerator RGS11/G beta 5S/R9AP is a constitutive heterotrimer selectively targeted to mGluR6 in ON-bipolar neurons
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GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexesNeuronal remodeling in retinal circuit assembly, disassembly, and reassemblyA Naturally Occurring Canine Model of Autosomal Recessive Congenital Stationary Night BlindnessAssociation between regulator of G protein signaling 9-2 and body weightMetabotropic glutamate receptors: from the workbench to the bedside.Membrane anchor R9AP potentiates GTPase-accelerating protein activity of RGS11 x Gbeta5 complex and accelerates inactivation of the mGluR6-G(o) signaling.RGS7 and -11 complexes accelerate the ON-bipolar cell light response.Nuclear localization of the G protein beta 5/R7-regulator of G protein signaling protein complex is dependent on R7 binding protein.RGS9 knockout causes a short delay in light responses of ON-bipolar cells.R9AP targeting to rod outer segments is independent of rhodopsin and is guided by the SNARE homology domain.Differential effects of the Gβ5-RGS7 complex on muscarinic M3 receptor-induced Ca2+ influx and release.Oligomeric state of purified transient receptor potential melastatin-1 (TRPM1), a protein essential for dim light vision.A conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins.R9AP stabilizes RGS11-G beta5 and accelerates the early light response of ON-bipolar cellsLocalization of Cacna1s to ON bipolar dendritic tips requires mGluR6-related cascade elements.A role for nyctalopin, a small leucine-rich repeat protein, in localizing the TRP melastatin 1 channel to retinal depolarizing bipolar cell dendritesTRPM1 forms complexes with nyctalopin in vivo and accumulates in postsynaptic compartment of ON-bipolar neurons in mGluR6-dependent manner.Differential function of Gγ13 in rod bipolar and ON cone bipolar cells.Targeted deletion of one or two copies of the G protein β subunit Gβ5 gene has distinct effects on body weight and behavior in mice.Regulator of G protein signaling 9-2 (RGS9-2) mRNA is up regulated during neuronal differentiation of mouse embryonic stem cells.Sensitivity and kinetics of signal transmission at the first visual synapse differentially impact visually-guided behavior.Orphan Receptor GPR158 Is an Allosteric Modulator of RGS7 Catalytic Activity with an Essential Role in Dictating Its Expression and Localization in the BrainmGluR6 deletion renders the TRPM1 channel in retina inactive.Defective retinal depolarizing bipolar cells in regulators of G protein signaling (RGS) 7 and 11 double null mice.Regulators of G protein signaling RGS7 and RGS11 determine the onset of the light response in ON bipolar neurons.Gβ3 is required for normal light ON responses and synaptic maintenanceThe relationship between slow photoresponse recovery rate and temporal resolution of vision.GIRK channel modulation by assembly with allosterically regulated RGS proteinsLRIT3 is essential to localize TRPM1 to the dendritic tips of depolarizing bipolar cells and may play a role in cone synapse formation.The TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein GoIntermolecular Interaction between Anchoring Subunits Specify Subcellular Targeting and Function of RGS Proteins in Retina ON-Bipolar NeuronsAmyloid Precursor-Like Protein 2 deletion-induced retinal synaptopathy related to congenital stationary night blindness: structural, functional and molecular characteristicsMutation of wrb, a Component of the Guided Entry of Tail-Anchored Protein Pathway, Disrupts Photoreceptor Synapse Structure and Function.Lack of mGluR6-related cascade elements leads to retrograde trans-synaptic effects on rod photoreceptor synapses via matrix-associated proteins.Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells.LRIT3 Differentially Affects Connectivity and Synaptic Transmission of Cones to ON- and OFF-Bipolar Cells.GPR179 is required for high sensitivity of the mGluR6 signaling cascade in depolarizing bipolar cells.Mouse b-wave mutants.Retinal bipolar cells: elementary building blocks of vision.Illuminating the multifaceted roles of neurotransmission in shaping neuronal circuitry.
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Retina-specific GTPase accelerator RGS11/G beta 5S/R9AP is a constitutive heterotrimer selectively targeted to mGluR6 in ON-bipolar neurons
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on July 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Retina-specific GTPase acceler ...... o mGluR6 in ON-bipolar neurons
@en
Retina-specific GTPase acceler ...... mGluR6 in ON-bipolar neurons.
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type
label
Retina-specific GTPase acceler ...... o mGluR6 in ON-bipolar neurons
@en
Retina-specific GTPase acceler ...... mGluR6 in ON-bipolar neurons.
@nl
prefLabel
Retina-specific GTPase acceler ...... o mGluR6 in ON-bipolar neurons
@en
Retina-specific GTPase acceler ...... mGluR6 in ON-bipolar neurons.
@nl
P2093
P2860
P1476
Retina-specific GTPase acceler ...... o mGluR6 in ON-bipolar neurons
@en
P2093
Alapakkam P Sampath
Dennis M Maddox
Haruhisa Okawa
Ikuo Masuho
Junko Asami
Keqiang Xie
Kirill A Martemyanov
Paul J Kammermeier
Takahisa Furukawa
Takayoshi Inoue
P2860
P304
P356
10.1523/JNEUROSCI.1367-09.2009
P407
P577
2009-07-01T00:00:00Z