Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells.
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G protein beta 5 is targeted to D2-dopamine receptor-containing biochemical compartments and blocks dopamine-dependent receptor internalizationGNB5 mutation causes a novel neuropsychiatric disorder featuring attention deficit hyperactivity disorder, severely impaired language development and normal cognitionAn allosteric regulator of R7-RGS proteins influences light-evoked activity and glutamatergic waves in the inner retina.Orphan Receptor GPR158 Is an Allosteric Modulator of RGS7 Catalytic Activity with an Essential Role in Dictating Its Expression and Localization in the BrainAssociation with the Plasma Membrane Is Sufficient for Potentiating Catalytic Activity of Regulators of G Protein Signaling (RGS) Proteins of the R7 Subfamily.Regulator of G Protein Signaling 7 (RGS7) Can Exist in a Homo-oligomeric Form That Is Regulated by Gαo and R7-binding Protein.Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors.Cellular and Subcellular Localization of the RGS7/Gβ5/R7BP Complex in the Cerebellar CortexRGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling.Differential localization of G protein βγ subunits.Regulator of G-Protein Signaling 7 Regulates Reward Behavior by Controlling Opioid Signaling in the Striatum.Monitoring G Protein Activation in Cells with BRET.Regulation of neurite morphogenesis by interaction between R7 regulator of G protein signaling complexes and G protein subunit Gα13.RGS2 modulates the activity and internalization of dopamine D2 receptors in neuroblastoma N2A cells.A central role for R7bp in the regulation of itch sensation.Quantitative Multiple-Reaction Monitoring Proteomic Analysis of Gβ and Gγ Subunits in C57Bl6/J Brain Synaptosomes.RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells.A High-Throughput Time-Resolved Fluorescence Energy Transfer Assay to Screen for Modulators of RGS7/Gβ5/R7BP Complex.Genetic Analysis of Rare Human Variants of Regulators of G Protein Signaling Proteins and Their Role in Human Physiology and Disease
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Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 15 July 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Macromolecular composition dic ...... ein complexes in living cells.
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Macromolecular composition dic ...... gulator of G protein signaling
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type
label
Macromolecular composition dic ...... ein complexes in living cells.
@en
Macromolecular composition dic ...... gulator of G protein signaling
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prefLabel
Macromolecular composition dic ...... ein complexes in living cells.
@en
Macromolecular composition dic ...... gulator of G protein signaling
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P2093
P2860
P356
P1476
Macromolecular composition dic ...... ein complexes in living cells.
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P2093
Ikuo Masuho
Keqiang Xie
Kirill A Martemyanov
P2860
P304
25129-25142
P356
10.1074/JBC.M113.462283
P407
P577
2013-07-15T00:00:00Z