X11alpha haploinsufficiency enhances Abeta amyloid deposition in Alzheimer's disease transgenic mice. - Wikidata - awgldk - TriplyDB

X11alpha haploinsufficiency enhances Abeta amyloid deposition in Alzheimer's disease transgenic mice.

X11alpha haploinsufficiency enhances Abeta amyloid deposition in Alzheimer's disease transgenic mice.

http://www.wikidata.org/entity/Q37343310

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A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6 Amyloid-beta Alzheimer targets - protein processing, lipid rafts, and amyloid-beta pores Cytoplasmic fragment of Alcadein α generated by regulated intramembrane proteolysis enhances amyloid β-protein precursor (APP) transport into the late secretory pathway and facilitates APP cleavage.Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in β-amyloid generation and Alzheimer's disease.X11/Mint genes control polarized localization of axonal membrane proteins in vivo Amyloid precursor protein processing and Alzheimer's disease Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain.Expression of the neuronal adaptor protein X11alpha protects against memory dysfunction in a transgenic mouse model of Alzheimer's disease.GULP1/CED-6 ameliorates amyloid-β toxicity in a Drosophila model of Alzheimer's disease.

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X11alpha haploinsufficiency enhances Abeta amyloid deposition in Alzheimer's disease transgenic mice.

http://www.wikidata.org/entity/Q37343310

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 23 July 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

X11alpha haploinsufficiency en ...... mer's disease transgenic mice.

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X11alpha haploinsufficiency en ...... mer's disease transgenic mice.

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X11alpha haploinsufficiency en ...... mer's disease transgenic mice.

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X11alpha haploinsufficiency en ...... mer's disease transgenic mice.

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X11alpha haploinsufficiency en ...... mer's disease transgenic mice.

@en

X11alpha haploinsufficiency en ...... mer's disease transgenic mice.

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J.NBD.2009.07.006

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Neurobiology of Disease

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X11alpha haploinsufficiency en ...... imer's disease transgenic mice

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Ashwin Gupta

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Henry Paulson

http://www.w3.org/2001/XMLSchema#string

Inderjeet Saluja

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P2860

Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting

Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein

Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism

Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's disease

Modulation of amyloid precursor protein metabolism by X11alpha /Mint-1. A deletion analysis of protein-protein interaction domains.

The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion

Mint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease

Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms

Mints, Munc18-interacting proteins in synaptic vesicle exocytosis

CASK associates with glutamate receptor interacting protein and signaling molecules

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162-168

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scholarly article

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10.1016/J.NBD.2009.07.006

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1

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Alzheimer's disease

haploinsufficiency

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2742573

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