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Genetically engineered mouse models of brain cancer and the promise of preclinical testing

Genetically engineered mouse models of brain cancer and the promise of preclinical testing

http://www.wikidata.org/entity/Q37348716

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Single and Multiple Gene Manipulations in Mouse Models of Human Cancer MR imaging features of high-grade gliomas in murine models: how they compare with human disease, reflect tumor biology, and play a role in preclinical trials Contemporary murine models in preclinical astrocytoma drug development Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations.Immunocompetent murine models for the study of glioblastoma immunotherapy Oncogene interactions are required for glioma development and progression as revealed by a tissue specific transgenic mouse model Mouse models for cancer stem cell research.Charting the course across the blood-brain barrier Uncertainty in the translation of preclinical experiments to clinical trials. Why do most phase III clinical trials fail?Toward 3D biomimetic models to understand the behavior of glioblastoma multiforme cells Stemness of the CT-2A Immunocompetent Mouse Brain Tumor Model: Characterization In Vitro Intratumoral mediated immunosuppression is prognostic in genetically engineered murine models of glioma and correlates to immunotherapeutic responses.CSF-1R inhibition alters macrophage polarization and blocks glioma progression.Heterogeneity maintenance in glioblastoma: a social network Establishment, maintenance and in vitro and in vivo applications of primary human glioblastoma multiforme (GBM) xenograft models for translational biology studies and drug discovery.Prevention against diffuse spinal cord astrocytoma: can the Notch pathway be a novel treatment target?Loss of p53 in quaking viable mice leads to Purkinje cell defects and reduced survival.HDM2 promotes WIP1-mediated medulloblastoma growth.Complex oncogenic signaling networks regulate brain tumor-initiating cells and their progenies: pivotal roles of wild-type EGFR, EGFRvIII mutant and hedgehog cascades and novel multitargeted therapies.Genetically engineered rat gliomas: PDGF-driven tumor initiation and progression in tv-a transgenic rats recreate key features of human brain cancer.Genetically engineered mouse models in cancer research Candidate pathways for promoting differentiation or quiescence of oligodendrocyte progenitor-like cells in glioma.How genetically engineered mouse tumor models provide insights into human cancers miR-124 inhibits STAT3 signaling to enhance T cell-mediated immune clearance of glioma Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas.Vascular Targeted Radioimmunotherapy for the Treatment of Glioblastoma.Expression of Idh1(R132H) in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis.Medulloblastomics: the end of the beginning.Mathematical modeling of PDGF-driven glioblastoma reveals optimized radiation dosing schedules Immunological considerations of modern animal models of malignant primary brain tumors.Signaling in malignant astrocytomas: role of neural stem cells and its therapeutic implications.Protein tyrosine phosphatases in glioma biology Gene therapy and virotherapy: novel therapeutic approaches for brain tumors.Molecular subclassification of diffuse gliomas: seeing order in the chaos.The Hedgehog's tale: developing strategies for targeting cancer.Matching mice to malignancy: molecular subgroups and models of medulloblastoma.Exploring molecular genetics of bladder cancer: lessons learned from mouse models Preclinical drug development for childhood cancer.The molecular landscape of diffuse glioma and prospects for biomarker development.Glioblastoma multiforme: a look inside its heterogeneous nature.

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Genetically engineered mouse models of brain cancer and the promise of preclinical testing

http://www.wikidata.org/entity/Q37348716

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on January 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Genetically engineered mouse m ...... promise of preclinical testing

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Genetically engineered mouse m ...... romise of preclinical testing.

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type

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Genetically engineered mouse m ...... promise of preclinical testing

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Genetically engineered mouse m ...... romise of preclinical testing.

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Genetically engineered mouse m ...... promise of preclinical testing

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Genetically engineered mouse m ...... romise of preclinical testing.

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J.1750-3639.2008.00234.X

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Brain Pathology

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Genetically engineered mouse m ...... promise of preclinical testing

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Eric C Holland

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Jason T Huse

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Creative Commons Attribution

P2860

ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

An integrated genomic analysis of human glioblastoma multiforme

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

Identification of a cancer stem cell in human brain tumors

Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system

Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects

Altered neural cell fates and medulloblastoma in mouse patched mutants

BRCA2 is required for neurogenesis and suppression of medulloblastoma

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scholarly article

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10.1111/J.1750-3639.2008.00234.X

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1

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2009-01-01T00:00:00Z

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19076778

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biomedical investigative technique

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2659383

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