Chemokine receptor antagonists: overcoming developmental hurdles.
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Folate receptor-β constitutes a marker for human proinflammatory monocytesPolymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme.Chemokines and Chemokine Receptors in the Development of Lupus NephritisTherapeutic potential of chemokine signal inhibition for metastatic breast cancerRegulation of atherogenesis by chemokines and chemokine receptorsChemokines and chemokine receptors: update on utility and challenges for the clinician.The Role of CC-Chemokines in the Regulation of AngiogenesisA novel CMKLR1 small molecule antagonist suppresses CNS autoimmune inflammatory diseaseElevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophagesThe role of chemokines in Guillain-Barré syndrome.Emerging concepts and approaches for chemokine-receptor drug discovery.HIV persistence: chemokines and their signalling pathways.TWEAK mediates inflammation in experimental atopic dermatitis and psoriasis.Defining the chemokine basis for leukocyte recruitment during viral encephalitis.The yin and yang of chemokine receptor activation.Role of chemokines in CNS health and pathology: a focus on the CCL2/CCR2 and CXCL8/CXCR2 networks.Regulation of the immune and inflammatory responses by the 'atypical' chemokine receptor D6.A novel highly potent therapeutic antibody neutralizes multiple human chemokines and mimics viral immune modulation.Therapeutic antibodies directed at G protein-coupled receptorsFragment-based optimization of small molecule CXCL12 inhibitors for antagonizing the CXCL12/CXCR4 interaction.The role of Ifng in alterations in liver gene expression in a mouse model of fulminant autoimmune hepatitisDirect measurement of thermal stability of expressed CCR5 and stabilization by small molecule ligands.Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain reliefMyeloid-derived suppressor cells regulate T cell and B cell responses during autoimmune diseaseChemokine mediated monocyte trafficking into the retina: role of inflammation in alteration of the blood-retinal barrier in diabetic retinopathy.Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways.Increased expression of CC chemokine ligand 18 in patients with chronic rhinosinusitis with nasal polyps.Fractalkine receptor CX(3)CR1 is expressed in epithelial ovarian carcinoma cells and required for motility and adhesion to peritoneal mesothelial cells.Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammationThe isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.The CCL2 synthesis inhibitor bindarit targets cells of the neurovascular unit, and suppresses experimental autoimmune encephalomyelitis.Chemokine (C-C motif) receptor 2 mediates mast cell migration to abdominal aortic aneurysm lesions in mice.Decoding the chemokine network that links leukocytes with decidual cells and the trophoblast during early implantation.Functional inhibition of chemokine receptor CCR2 by dicer-substrate-siRNA prevents pain developmentThe lupane-type triterpene 30-oxo-calenduladiol is a CCR5 antagonist with anti-HIV-1 and anti-chemotactic activities.PET/CT Imaging of Chemokine Receptors in Inflammatory Atherosclerosis Using Targeted Nanoparticles.CCR2 and CXCR4 regulate peripheral blood monocyte pharmacodynamics and link to efficacy in experimental autoimmune encephalomyelitis.Hetero-oligomerization of CCR2, CCR5, and CXCR4 and the protean effects of "selective" antagonists.International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors.Osteoarthritis: toward a comprehensive understanding of pathological mechanism.
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Chemokine receptor antagonists: overcoming developmental hurdles.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 12 December 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Chemokine receptor antagonists: overcoming developmental hurdles.
@en
Chemokine receptor antagonists: overcoming developmental hurdles.
@nl
type
label
Chemokine receptor antagonists: overcoming developmental hurdles.
@en
Chemokine receptor antagonists: overcoming developmental hurdles.
@nl
prefLabel
Chemokine receptor antagonists: overcoming developmental hurdles.
@en
Chemokine receptor antagonists: overcoming developmental hurdles.
@nl
P356
P1476
Chemokine receptor antagonists: overcoming developmental hurdles.
@en
P2093
Richard Horuk
P2888
P356
10.1038/NRD2734
P577
2008-12-12T00:00:00Z