Mcl-1 is a potential therapeutic target in multiple types of cancer.
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Role of bile salt in regulating Mcl-1 phosphorylation and chemoresistance in hepatocellular carcinoma cellsMcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell linesApigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cellsApoptosis, autophagy and unfolded protein response pathways in Arbovirus replication and pathogenesisThe two faces of miR-29Targeting Mcl-1 for the therapy of cancerThe MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizerCDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma CellsAclacinomycin A sensitizes K562 chronic myeloid leukemia cells to imatinib through p38MAPK-mediated erythroid differentiationRegulation of Mcl-1 by SRSF1 and SRSF5 in cancer cellsBcl-2high mantle cell lymphoma cells are sensitized to acadesine with ABT-199.HTLV-1-associated adult T cell leukemia is highly susceptible to Navitoclax due to enhanced Bax expression.The Bcl-2/xL inhibitor ABT-263 increases the stability of Mcl-1 mRNA and protein in hepatocellular carcinoma cells.Vascular endothelial growth factor regulates myeloid cell leukemia-1 expression through neuropilin-1-dependent activation of c-MET signaling in human prostate cancer cells.Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim.Estrogen regulation of anti-apoptotic Bcl-2 family member Mcl-1 expression in breast cancer cellsA survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy.Targeting MCL-1 sensitizes human esophageal squamous cell carcinoma cells to cisplatin-induced apoptosisSystems analysis of protein modification and cellular responses induced by electrophile stress.Investigation into omacetaxine solution stability for in vitro study.Marinopyrrole derivatives with sulfide spacers as selective disruptors of Mcl-1 binding to pro-apoptotic protein Bim.Function of UDP-glucuronosyltransferase 2B17 (UGT2B17) is involved in endometrial cancerSorafenib: complexities of Raf-dependent and Raf-independent signaling are now unveiled.Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation.Epidermal growth factor receptor (EGFR) signaling promotes proliferation and survival in osteoprogenitors by increasing early growth response 2 (EGR2) expressionRole of Ku70 in deubiquitination of Mcl-1 and suppression of apoptosis.Serine 162, an essential residue for the mitochondrial localization, stability and anti-apoptotic function of Mcl-1.Design, synthesis and evaluation of marinopyrrole derivatives as selective inhibitors of Mcl-1 binding to pro-apoptotic Bim and dual Mcl-1/Bcl-xL inhibitors.Overexpression of Mcl-1L splice variant is associated with poor prognosis and chemoresistance in oral cancers.The stress protein BAG3 stabilizes Mcl-1 protein and promotes survival of cancer cells and resistance to antagonist ABT-737Concurrent inhibition of PI3K and mTORC1/mTORC2 overcomes resistance to rapamycin induced apoptosis by down-regulation of Mcl-1 in mantle cell lymphoma.SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destructionSynergistic interaction between the HDAC inhibitor, MPT0E028, and sorafenib in liver cancer cells in vitro and in vivoAnti-apoptotic activity and proteasome-mediated degradation of Xenopus Mcl-1 protein in egg extracts.Myeloid cell leukemia-1 is associated with tumor progression by inhibiting apoptosis and enhancing angiogenesis in colorectal cancer.Anti-apoptotic role of HIF-1 and AP-1 in paclitaxel exposed breast cancer cells under hypoxiaMCL-1ES induces MCL-1L-dependent BAX- and BAK-independent mitochondrial apoptosis.Quercetin downregulates Mcl-1 by acting on mRNA stability and protein degradation.Epidermal growth factor regulates Mcl-1 expression through the MAPK-Elk-1 signalling pathway contributing to cell survival in breast cancer
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Mcl-1 is a potential therapeutic target in multiple types of cancer.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Mcl-1 is a potential therapeutic target in multiple types of cancer.
@en
Mcl-1 is a potential therapeutic target in multiple types of cancer.
@nl
type
label
Mcl-1 is a potential therapeutic target in multiple types of cancer.
@en
Mcl-1 is a potential therapeutic target in multiple types of cancer.
@nl
prefLabel
Mcl-1 is a potential therapeutic target in multiple types of cancer.
@en
Mcl-1 is a potential therapeutic target in multiple types of cancer.
@nl
P1476
Mcl-1 is a potential therapeutic target in multiple types of cancer.
@en
P2093
P2888
P304
P356
10.1007/S00018-008-8637-6
P577
2009-04-01T00:00:00Z