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WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcriptionChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repairEnhancement of RAD51 recombinase activity by the tumor suppressor PALB2.MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaksStructural basis for recruitment of BRCA2 by PALB2PALB2 regulates recombinational repair through chromatin association and oligomerizationBreast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forksThe role of the human SWI5-MEI5 complex in homologous recombination repairBreast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repairDynamics of DNA damage response proteins at DNA breaks: a focus on protein modificationsSusceptibility pathways in Fanconi's anemia and breast cancerTherapeutic Implications for Overcoming Radiation Resistance in Cancer TherapyExploiting the Fanconi Anemia Pathway for Targeted Anti-Cancer TherapyDouble-strand break repair on sex chromosomes: challenges during male meiotic prophaseFanconi anemia pathway defects in inherited and sporadic cancersBRCA1, a 'complex' protein involved in the maintenance of genomic stabilityInteraction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2Personalizing cancer treatment in the age of global genomic analyses: PALB2 gene mutations and the response to DNA damaging agents in pancreatic cancer.Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteinsMolding BRCA2 function through its interacting partnersPALB2: the hub of a network of tumor suppressors involved in DNA damage responsesMitotic homologous recombination maintains genomic stability and suppresses tumorigenesisRAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombinationCooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombinationGetting personalized cancer genome analysis into the clinic: the challenges in bioinformaticsLoss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppressionPalb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancerExpanded roles of the Fanconi anemia pathway in preserving genomic stabilityThe role of the Fanconi anemia network in the response to DNA replication stress.A novel germline PALB2 deletion in Polish breast and ovarian cancer patientsCancer-causing mutations in the tumor suppressor PALB2 reveal a novel cancer mechanism using a hidden nuclear export signal in the WD40 repeat motifPALB2 variants in hereditary and unselected Finnish prostate cancer cases.Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistanceBRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis.DNA double-strand break repair genes and oxidative damage in brain metastasis of breast cancer.Chronic treatment with cisplatin induces chemoresistance through the TIP60-mediated Fanconi anemia and homologous recombination repair pathways.EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: implications for chromosomal instability/recombination syndromes as checkpoint diseases.Targeting reactive nitrogen species suppresses hereditary pancreatic cancer.beta1-integrin is dispensable for the induction of ErbB2 mammary tumors but plays a critical role in the metastatic phase of tumor progressionMale fertility defect associated with disrupted BRCA1-PALB2 interaction in mice
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 05 March 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
PALB2 links BRCA1 and BRCA2 in the DNA-damage response.
@en
PALB2 links BRCA1 and BRCA2 in the DNA-damage response.
@nl
type
label
PALB2 links BRCA1 and BRCA2 in the DNA-damage response.
@en
PALB2 links BRCA1 and BRCA2 in the DNA-damage response.
@nl
prefLabel
PALB2 links BRCA1 and BRCA2 in the DNA-damage response.
@en
PALB2 links BRCA1 and BRCA2 in the DNA-damage response.
@nl
P2093
P2860
P1433
P1476
PALB2 links BRCA1 and BRCA2 in the DNA-damage response.
@en
P2093
Feng Zhang
Jianglin Ma
Xiaochun Yu
P2860
P304
P356
10.1016/J.CUB.2009.02.018
P407
P577
2009-03-05T00:00:00Z