Differentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line, HIT-T15
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Heat shock protein 60 modified with O-linked N-acetylglucosamine is involved in pancreatic beta-cell death under hyperglycemic conditionsGLP1-derived nonapeptide GLP1(28-36)amide protects pancreatic β-cells from glucolipotoxicitymtDNA G10398A variation provides risk to type 2 diabetes in population group from the Jammu region of India.Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants.Endoplasmic reticulum stress and insulin biosynthesis: a reviewDevelopmental origins of adult disease.The JNK pathway as a therapeutic target for diabetes.Developmental origins of diabetes: The role of oxidative stressInvestigational agents that protect pancreatic islet beta-cells from failure.Glucolipotoxicity: fuel excess and beta-cell dysfunction.Stress-impaired transcription factor expression and insulin secretion in transplanted human islets.Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis.Involvement of oxidative stress in suppression of insulin biosynthesis under diabetic conditions.Down-regulation of pancreatic transcription factors and incretin receptors in type 2 diabetes.Suppression of transcription factor PDX-1/IPF1/STF-1/IDX-1 causes no decrease in insulin mRNA in MIN6 cells.Role of pancreatic transcription factors in maintenance of mature β-cell function.Understanding Genetic Heterogeneity in Type 2 Diabetes by Delineating Physiological Phenotypes: SIRT1 and its Gene Network in Impaired Insulin Secretion.Coordinate changes in histone modifications, mRNA levels, and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity.Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein beta and transactivator islet duodenum homeobox-1 in rat pancreatic beta cells during the development of diabetes mellitus.Determinants of glucose toxicity and its reversibility in the pancreatic islet beta-cell line, HIT-T15.Involvement of oxidative stress and the JNK pathway in glucose toxicity.Potentiation of insulin-related signal transduction by a novel protein-tyrosine phosphatase inhibitor, Et-3,4-dephostatin, on cultured 3T3-L1 adipocytes.Effect of gelam honey on the oxidative stress-induced signaling pathways in pancreatic hamster cells.Glucose induces and leptin decreases expression of uncoupling protein-2 mRNA in human islets.Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, protects the pancreas from apoptosis and proliferation via oxidative stress in streptozotocin-induced diabetic rats.Improvement of isolated caprine islet survival and functionality in vitro by enhancing of PDX1 gene expression.
P2860
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P2860
Differentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line, HIT-T15
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 1997
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
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name
Differentiation of glucose tox ...... eatic islet cell line, HIT-T15
@en
Differentiation of glucose tox ...... atic islet cell line, HIT-T15.
@nl
type
label
Differentiation of glucose tox ...... eatic islet cell line, HIT-T15
@en
Differentiation of glucose tox ...... atic islet cell line, HIT-T15.
@nl
prefLabel
Differentiation of glucose tox ...... eatic islet cell line, HIT-T15
@en
Differentiation of glucose tox ...... atic islet cell line, HIT-T15.
@nl
P2093
P2860
P921
P356
P1476
Differentiation of glucose tox ...... eatic islet cell line, HIT-T15
@en
P2093
P2860
P304
P356
10.1172/JCI119190
P407
P577
1997-02-01T00:00:00Z