Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator.
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Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitusHeat shock protein 60 modified with O-linked N-acetylglucosamine is involved in pancreatic beta-cell death under hyperglycemic conditionsInhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicityThe role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells.An islet in distress: β cell failure in type 2 diabetes.Multiple chromatin-bound protein kinases assemble factors that regulate insulin gene transcription.The activation of the rat insulin gene II by BETA2 and PDX-1 in rat insulinoma cells is repressed by Pax6Regulation of MafA expression in pancreatic beta-cells in db/db mice with diabetes.A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity.Pancreatic Duodenal Homeobox (PDX-1) in health and disease.Glucolipotoxicity in Pancreatic β-Cells.Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants.The brown seaweed Sargassum hemiphyllum exhibits α-amylase and α-glucosidase inhibitory activity and enhances insulin release in vitro.Glucose induces MafA expression in pancreatic beta cell lines via the hexosamine biosynthetic pathway.Inhibition of Small Maf Function in Pancreatic β-Cells Improves Glucose Tolerance Through the Enhancement of Insulin Gene Transcription and Insulin Secretion.Investigational agents that protect pancreatic islet beta-cells from failure.Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases insulin gene expression via up-regulation of orphan nuclear receptor small heterodimer partner.Glucolipotoxicity: fuel excess and beta-cell dysfunction.Ebselen treatment prevents islet apoptosis, maintains intranuclear Pdx-1 and MafA levels, and preserves β-cell mass and function in ZDF ratsDifferentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line, HIT-T15beta-Cell-specific overexpression of glutathione peroxidase preserves intranuclear MafA and reverses diabetes in db/db mice.Discovery, Synthesis, and Evaluation of 2,4-Diaminoquinazolines as a Novel Class of Pancreatic β-Cell-Protective Agents against Endoplasmic Reticulum (ER) Stress.Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes.Microenvironmental stimuli for proliferation of functional islet β-cells.Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis.MafA and MafB activity in pancreatic β cells.Involvement of oxidative stress in suppression of insulin biosynthesis under diabetic conditions.Diabetes and beta cell function: from mechanisms to evaluation and clinical implications.Down-regulation of pancreatic transcription factors and incretin receptors in type 2 diabetes.Suppression of transcription factor PDX-1/IPF1/STF-1/IDX-1 causes no decrease in insulin mRNA in MIN6 cells.Role of pancreatic transcription factors in maintenance of mature β-cell function.Phosphorylation of MafA enhances interaction with Beta2/NeuroD1.Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein beta and transactivator islet duodenum homeobox-1 in rat pancreatic beta cells during the development of diabetes mellitus.Role of high-voltage-activated calcium channels in glucose-regulated beta-cell calcium homeostasis and insulin release.Determinants of glucose toxicity and its reversibility in the pancreatic islet beta-cell line, HIT-T15.Transcription factors recognizing overlapping C1-A2 binding sites positively regulate insulin gene expression.The RIPE3b1 activator of the insulin gene is composed of a protein(s) of approximately 43 kDa, whose DNA binding activity is inhibited by protein phosphatase treatment.Pleiotropic Roles of PDX-1 in the PancreasD-Glyceraldehyde causes production of intracellular peroxide in pancreatic islets, oxidative stress, and defective beta cell function via non-mitochondrial pathways.ERp46 is reduced by high glucose and regulates insulin content in pancreatic beta-cells.
P2860
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P2860
Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Chronic exposure of betaTC-6 c ...... gene transcription activator.
@en
Chronic exposure of betaTC-6 c ...... gene transcription activator.
@nl
type
label
Chronic exposure of betaTC-6 c ...... gene transcription activator.
@en
Chronic exposure of betaTC-6 c ...... gene transcription activator.
@nl
prefLabel
Chronic exposure of betaTC-6 c ...... gene transcription activator.
@en
Chronic exposure of betaTC-6 c ...... gene transcription activator.
@nl
P2093
P2860
P921
P356
P1476
Chronic exposure of betaTC-6 c ...... gene transcription activator.
@en
P2093
R P Robertson
P2860
P304
P356
10.1172/JCI118496
P407
P577
1996-02-01T00:00:00Z