T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity.
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Large scale characterization of the LC13 TCR and HLA-B8 structural landscape in reaction to 172 altered peptide ligands: a molecular dynamics simulation studyIdentifying Individual T Cell Receptors of Optimal Avidity for Tumor AntigensNarrowing the Gap: Preserving Repertoire Diversity Despite Clonal Selection during the CD4 T Cell ResponseExperimental and theoretical bases for mechanisms of antigen discrimination by T cellsTo affinity and beyond: harnessing the T cell receptor for cancer immunotherapyIndoctrinating T cells to attack pathogens through homeschoolingNKG2D ligands as therapeutic targetsMechanical regulation of T-cell functionsQuantifying biomass changes of single CD8+ T cells during antigen specific cytotoxicityT cell receptor-like recognition of tumor in vivo by synthetic antibody fragmentStructure of a TCR with high affinity for self-antigen reveals basis for escape from negative selectionA Role for Differential Variable Gene Pairing in Creating T Cell Receptors Specific for Unique Major Histocompatibility LigandsComputational Design of the Affinity and Specificity of a Therapeutic T Cell ReceptorProline substitution independently enhances H-2D(b) complex stabilization and TCR recognition of melanoma-associated peptidesRecent advances in T-cell engineering for use in immunotherapyGlobosides but not isoglobosides can impact the development of invariant NKT cells and their interaction with dendritic cellsAffinity flow fractionation of cells via transient interactions with asymmetric molecular patterns.Novel approaches for identifying target antigens of autoreactive human B and T cellsIdentification of multiple public TCR repertoires in chronic beryllium disease.Physics of cell adhesion: some lessons from cell-mimetic systems.An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role.Fast on-rates allow short dwell time ligands to activate T cells.Sequential immunization with heterologous chimeric flaviviruses induces broad-spectrum cross-reactive CD8+ T cell responses.The basic principles of chimeric antigen receptor design.The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness.Rebalancing immune specificity and function in cancer by T-cell receptor gene therapy.CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery.Different affinity windows for virus and cancer-specific T-cell receptors: implications for therapeutic strategiesSpecific increase in potency via structure-based design of a TCR.Sequence, structure, function, immunity: structural genomics of costimulation.Engineering improved T cell receptors using an alanine-scan guided T cell display selection systemIdentification and engineering of human variable regions that allow expression of stable single-chain T cell receptors.A novel T cell receptor single-chain signaling complex mediates antigen-specific T cell activity and tumor controlMolecules in medicine mini review: the αβ T cell receptor.Models of self-peptide sampling by developing T cells identify candidate mechanisms of thymic selection.A detailed mathematical model predicts that serial engagement of IgE-Fc epsilon RI complexes can enhance Syk activation in mast cells.The tumor targeted superantigen ABR-217620 selectively engages TRBV7-9 and exploits TCR-pMHC affinity mimicry in mediating T cell cytotoxicity.T-cell reprogramming through targeted CD4-coreceptor and T-cell receptor expression on maturing thymocytes by latent Circoviridae family member porcine circovirus type 2 cell infections in the thymus.T cell receptor binding affinity governs the functional profile of cancer-specific CD8+ T cellsT Cell Receptor Engineering and Analysis Using the Yeast Display Platform.
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T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
T-cell receptor binding affini ...... cell activity and specificity.
@en
T-cell receptor binding affini ...... cell activity and specificity.
@nl
type
label
T-cell receptor binding affini ...... cell activity and specificity.
@en
T-cell receptor binding affini ...... cell activity and specificity.
@nl
prefLabel
T-cell receptor binding affini ...... cell activity and specificity.
@en
T-cell receptor binding affini ...... cell activity and specificity.
@nl
P2093
P2860
P1433
P1476
T-cell receptor binding affini ...... cell activity and specificity.
@en
P2093
Adam S Chervin
David M Kranz
Jennifer D Stone
P2860
P304
P356
10.1111/J.1365-2567.2008.03015.X
P577
2009-02-01T00:00:00Z