Reciprocal efficiency of RNQ1 and polyglutamine detoxification in the cytosol and nucleus.
about
The [RNQ+] prion: a model of both functional and pathological amyloidThe Hsp70/90 cochaperone, Sti1, suppresses proteotoxicity by regulating spatial quality control of amyloid-like proteins.Modeling Huntington disease in yeast: perspectives and future directions.Polyglutamine-rich suppressors of huntingtin toxicity act upstream of Hsp70 and Sti1 in spatial quality control of amyloid-like proteins.Use of yeast as a system to study amyloid toxicityOverexpression of the essential Sis1 chaperone reduces TDP-43 effects on toxicity and proteolysis.Prion-promoted phosphorylation of heterologous amyloid is coupled with ubiquitin-proteasome system inhibition and toxicity.Defining the limits: Protein aggregation and toxicity in vivoThe Type II Hsp40 Sis1 cooperates with Hsp70 and the E3 ligase Ubr1 to promote degradation of terminally misfolded cytosolic protein.Heterologous gln/asn-rich proteins impede the propagation of yeast prions by altering chaperone availabilitySpatial quality control bypasses cell-based limitations on proteostasis to promote prion curing.Overexpression of Q-rich prion-like proteins suppresses polyQ cytotoxicity and alters the polyQ interactome.Localization of HET-S to the cell periphery, not to [Het-s] aggregates, is associated with [Het-s]-HET-S toxicity.Structural variants of yeast prions show conformer-specific requirements for chaperone activity.CAG Expansions Are Genetically Stable and Form Nontoxic Aggregates in Cells Lacking Endogenous Polyglutamine ProteinsInterplay between protein homeostasis networks in protein aggregation and proteotoxicityAmyloid in neurodegenerative diseases: friend or foe?Contribution of yeast models to neurodegeneration research.Comparative Analysis of Mutant Huntingtin Binding Partners in Yeast Species.
P2860
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P2860
Reciprocal efficiency of RNQ1 and polyglutamine detoxification in the cytosol and nucleus.
description
article científic
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article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 05 August 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Reciprocal efficiency of RNQ1 ...... on in the cytosol and nucleus.
@en
Reciprocal efficiency of RNQ1 ...... on in the cytosol and nucleus.
@nl
type
label
Reciprocal efficiency of RNQ1 ...... on in the cytosol and nucleus.
@en
Reciprocal efficiency of RNQ1 ...... on in the cytosol and nucleus.
@nl
prefLabel
Reciprocal efficiency of RNQ1 ...... on in the cytosol and nucleus.
@en
Reciprocal efficiency of RNQ1 ...... on in the cytosol and nucleus.
@nl
P2093
P2860
P356
P1476
Reciprocal efficiency of RNQ1 ...... on in the cytosol and nucleus.
@en
P2093
Daniel W Summers
Douglas M Cyr
Hong-Yu Ren
Peter M Douglas
P2860
P304
P356
10.1091/MBC.E09-02-0170
P577
2009-08-05T00:00:00Z