The hedgehog pathway transcription factor GLI1 promotes malignant behavior of cancer cells by up-regulating osteopontin. - Wikidata - awgldk - TriplyDB

The hedgehog pathway transcription factor GLI1 promotes malignant behavior of cancer cells by up-regulating osteopontin.

The hedgehog pathway transcription factor GLI1 promotes malignant behavior of cancer cells by up-regulating osteopontin.

http://www.wikidata.org/entity/Q37371674

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The hedgehog pathway in triple-negative breast cancer Osteopontin-A Master Regulator of Epithelial-Mesenchymal Transition Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer A structure-based approach for mapping adverse drug reactions to the perturbation of underlying biological pathways Irradiated riboflavin diminishes the aggressiveness of melanoma in vitro and in vivo Cancer biomarker discovery: the entropic hallmark.Targeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration.MiR-133b is frequently decreased in gastric cancer and its overexpression reduces the metastatic potential of gastric cancer cells.Itraconazole exerts its anti-melanoma effect by suppressing Hedgehog, Wnt, and PI3K/mTOR signaling pathways Hedgehog signaling in the normal and neoplastic mammary gland.Targeting Hedgehog--a cancer stem cell pathway Gli1 promotes cell survival and is predictive of a poor outcome in ERalpha-negative breast cancer.Gene expression profiling of the hedgehog signaling pathway in human meningiomas.Hedgehog signaling in tumor cells facilitates osteoblast-enhanced osteolytic metastases Micro-RNA-632 downregulates DNAJB6 in breast cancer.Pancreatic cancer spheres are more than just aggregates of stem marker-positive cells.Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis.MITF-independent pro-survival role of BRG1-containing SWI/SNF complex in melanoma cells.Hedgehog signaling induced by breast cancer cells promotes osteoclastogenesis and osteolysis.Gli1 enhances migration and invasion via up-regulation of MMP-11 and promotes metastasis in ERα negative breast cancer cell lines.Increased vascularity and spontaneous metastasis of breast cancer by hedgehog signaling mediated upregulation of cyr61.Survivin, a novel target of the Hedgehog/GLI signaling pathway in human tumor cells Nonclassical activation of Hedgehog signaling enhances multidrug resistance and makes cancer cells refractory to Smoothened-targeting Hedgehog inhibition Osteopontin is a novel downstream target of SOX9 with diagnostic implications for progression of liver fibrosis in humans.DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3β to downregulate β-catenin transcription target, osteopontin Cross-talk between Human Papillomavirus Oncoproteins and Hedgehog Signaling Synergistically Promotes Stemness in Cervical Cancer Cells Phytoestrogens regulate the proliferation and expression of stem cell factors in cell lines of malignant testicular germ cell tumors Wnt and related signaling pathways in melanomagenesis.Hedgehog pathway blockade inhibits melanoma cell growth in vitro and in vivo.Loss of Merlin induces metabolomic adaptation that engages dependence on Hedgehog signaling.Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals Genomic regulation of invasion by STAT3 in triple negative breast cancer.Sonic hedgehog pathway contributes to gastric cancer cell growth and proliferation.The embryonic type of SPP1 transcriptional regulation is re-activated in glioblastoma.Predicting and preventing melanoma invasiveness: advances in clarifying E2F1 function.The Human Glioma-Associated Oncogene Homolog 1 (GLI1) Family of Transcription Factors in Gene Regulation and Diseases.Hedgehog signaling in skin cancers Recent advances in anti-angiogenic therapy of cancer

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The hedgehog pathway transcription factor GLI1 promotes malignant behavior of cancer cells by up-regulating osteopontin.

http://www.wikidata.org/entity/Q37371674

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 25 June 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

The hedgehog pathway transcrip ...... by up-regulating osteopontin.

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The hedgehog pathway transcrip ...... by up-regulating osteopontin.

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type

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The hedgehog pathway transcrip ...... by up-regulating osteopontin.

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The hedgehog pathway transcrip ...... by up-regulating osteopontin.

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The hedgehog pathway transcrip ...... by up-regulating osteopontin.

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The hedgehog pathway transcrip ...... by up-regulating osteopontin.

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JBC.M109.021949

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Journal of Biological Chemistry

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The hedgehog pathway transcrip ...... by up-regulating osteopontin.

@en

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Adam I Riker

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Brandon J Metge

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Lalita A Shevde

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Lillianne G Harris

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Rajeev S Samant

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Shamik Das

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Suhu Liu

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P2860

Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-kappaB activation

Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney

Small molecule modulation of Smoothened activity

A role of PDGFRalpha in basal cell carcinoma proliferation

A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube

The GLI gene encodes a nuclear protein which binds specific sequences in the human genome

Small C-terminal domain phosphatase enhances snail activity through dephosphorylation

Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation

Hedgehog signaling in animal development: paradigms and principles

A biochemical characterization of the binding of osteopontin to integrins alpha v beta 1 and alpha v beta 5

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10.1074/JBC.M109.021949

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