Amyloid-β forms fibrils by nucleated conformational conversion of oligomers
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NDUFA12L mitochondrial complex-I assembly factor: Implications for taupathiesTau Oligomers: The Toxic Player at Synapses in Alzheimer's DiseaseFluid Biomarkers in Clinical Trials of Alzheimer's Disease TherapeuticsPhysicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)Dementia of the eye: the role of amyloid beta in retinal degenerationSelf-propagation of pathogenic protein aggregates in neurodegenerative diseasesStructural Conversion of Aβ17-42 Peptides from Disordered Oligomers to U-Shape Protofilaments via Multiple Kinetic PathwaysMolecular basis of -amyloid oligomer recognition with a conformational antibody fragmentAromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent ConjugateA Nanobody Binding to Non-Amyloidogenic Regions of the Protein Human Lysozyme Enhances Partial Unfolding but Inhibits Amyloid Fibril FormationAdvances in chemical labeling of proteins in living cellsAmyloid-β oligomers are sequestered by both intracellular and extracellular chaperonesMapping the structure of amyloid nucleation precursors by protein engineering kinetic analysis.The binding of apolipoprotein E to oligomers and fibrils of amyloid-β alters the kinetics of amyloid aggregation.Antiparallel triple-strand architecture for prefibrillar Aβ42 oligomersNeurotoxic amyloid beta oligomeric assemblies recreated in microfluidic platform with interstitial level of slow flowUltrafast propagation of β-amyloid fibrils in oligomeric cloud.Effect of metals on kinetic pathways of amyloid-β aggregationBiophysical underpinnings of the repeat length dependence of polyglutamine amyloid formationThe complexities underlying age-related macular degeneration: could amyloid beta play an important role?Direct observations of amyloid β self-assembly in live cells provide insights into differences in the kinetics of Aβ(1-40) and Aβ(1-42) aggregation.Immunoprecipitation of amyloid fibrils by the use of an antibody that recognizes a generic epitope common to amyloid fibrils.Atomic-resolution dynamics on the surface of amyloid-β protofibrils probed by solution NMRProliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism.Unmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation.Specific aromatic foldamers potently inhibit spontaneous and seeded Aβ42 and Aβ43 fibril assembly.Surface effects mediate self-assembly of amyloid-β peptides.Effects of macromolecular crowding on amyloid beta (16-22) aggregation using coarse-grained simulations.Crucial role of nonspecific interactions in amyloid nucleation.Particle size of latex beads dictates IL-1β production mechanism.Minimal model of self-assembly: emergence of diversity and complexity.Visualizing protein partnerships in living cells and organisms.High-resolution NMR characterization of low abundance oligomers of amyloid-β without purificationA molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomersSDS-PAGE analysis of Aβ oligomers is disserving research into Alzheimer´s disease: appealing for ESI-IM-MSTargeting protein aggregation for the treatment of degenerative diseasesTau Aggregation Propensity Engrained in Its Solution State.Selective inhibition of aggregation/fibrillation of bovine serum albumin by osmolytes: Mechanistic and energetics insights.Fibrils colocalize caspase-3 with procaspase-3 to foster maturation.Stability of early-stage amyloid-β(1-42) aggregation species.
P2860
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P2860
Amyloid-β forms fibrils by nucleated conformational conversion of oligomers
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Amyloid-β forms fibrils by nucleated conformational conversion of oligomers
@en
Amyloid-β forms fibrils by nucleated conformational conversion of oligomers
@nl
type
label
Amyloid-β forms fibrils by nucleated conformational conversion of oligomers
@en
Amyloid-β forms fibrils by nucleated conformational conversion of oligomers
@nl
prefLabel
Amyloid-β forms fibrils by nucleated conformational conversion of oligomers
@en
Amyloid-β forms fibrils by nucleated conformational conversion of oligomers
@nl
P2860
P50
P356
P1476
Amyloid-β forms fibrils by nucleated conformational conversion of oligomers
@en
P2093
Elizabeth K Culyba
P2860
P2888
P304
P356
10.1038/NCHEMBIO.624
P577
2011-07-31T00:00:00Z
P5875
P6179
1006799700