Tau pathophysiology in neurodegeneration: a tangled issue.
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SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's diseaseImpaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic miceAmyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastinFour decades of neurodegenerative disease research: how far we have come!Insight into the Molecular Imaging of Alzheimer's DiseaseFrontotemporal lobar degeneration: old knowledge and new insight into the pathogenetic mechanisms of tau mutationsLysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivoSpines, plasticity, and cognition in Alzheimer's model miceBlood biomarkers for brain injury: What are we measuring?Function and regulation of tau conformations in the development and treatment of traumatic brain injury and neurodegenerationSystems biology of neurodegenerative diseasesTau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brainProtein misfolding and aggregation in Alzheimer's disease and type 2 diabetes mellitusEnhancement of proteasome activity by a small-molecule inhibitor of USP14Electrophysiological changes precede morphological changes to frontal cortical pyramidal neurons in the rTg4510 mouse model of progressive tauopathyNeurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo.Senescence-accelerated OXYS rats: a model of age-related cognitive decline with relevance to abnormalities in Alzheimer disease.Glial contributions to neurodegeneration in tauopathies.Dendritic vulnerability in neurodegenerative disease: insights from analyses of cortical pyramidal neurons in transgenic mouse modelsTau phosphorylation induced by severe closed head traumatic brain injury is linked to the cellular prion proteinCross-talk of membrane lipids and Alzheimer-related proteins.CSF biomarkers in prediction of cerebral and clinical change in mild cognitive impairment and Alzheimer's disease.Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport.Death-associated protein kinase 1 has a critical role in aberrant tau protein regulation and function.Mapping Alzheimer's disease progression in 1309 MRI scans: power estimates for different inter-scan intervals.Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs.Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease.New tools for the study of Alzheimer's disease: what are biomarkers and morphometric markers teaching us?Cu, Zn-superoxide dismutase 1 (SOD1) is a novel target of Puromycin-sensitive aminopeptidase (PSA/NPEPPS): PSA/NPEPPS is a possible modifier of amyotrophic lateral sclerosis.Versatile somatic gene transfer for modeling neurodegenerative diseases.Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer's disease.Cognitive decline is associated with reduced reelin expression in the entorhinal cortex of aged ratsTau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses.Brain atrophy in healthy aging is related to CSF levels of Aβ1-42.Mitochondria-derived reactive oxygen species mediate caspase-dependent and -independent neuronal deaths.Models of β-amyloid induced Tau-pathology: the long and "folded" road to understand the mechanism.Genetic loci associated with Alzheimer's disease and cerebrospinal fluid biomarkers in a Finnish case-control cohort.AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer's disease and other tauopathies.Caspase Cleaved Tau in Alzheimer's Disease: A Therapeutic Target Realized.Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy
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Tau pathophysiology in neurodegeneration: a tangled issue.
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 21 January 2009
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vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Tau pathophysiology in neurodegeneration: a tangled issue.
@en
Tau pathophysiology in neurodegeneration: a tangled issue.
@nl
type
label
Tau pathophysiology in neurodegeneration: a tangled issue.
@en
Tau pathophysiology in neurodegeneration: a tangled issue.
@nl
prefLabel
Tau pathophysiology in neurodegeneration: a tangled issue.
@en
Tau pathophysiology in neurodegeneration: a tangled issue.
@nl
P2093
P1476
Tau pathophysiology in neurodegeneration: a tangled issue.
@en
P2093
Alix de Calignon
Phillip B Jones
William H Stoothoff
P304
P356
10.1016/J.TINS.2008.11.007
P577
2009-01-21T00:00:00Z