Protein promiscuity and its implications for biotechnology.
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How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusionPredicting new molecular targets for known drugsCatalytic Promiscuity of the Radical S-adenosyl-L-methionine Enzyme NosLDrug Repurposing Is a New Opportunity for Developing Drugs against Neuropsychiatric DisordersModeling for (physical) biologists: an introduction to the rule-based approachHDAC8 substrates: Histones and beyondHydrophobicity and charge shape cellular metabolite concentrationsUltrahigh-throughput discovery of promiscuous enzymes by picodroplet functional metagenomics.Multiple Conformers in Active Site of Human Dihydrofolate Reductase F31R/Q35E Double Mutant Suggest Structural Basis for Methotrexate ResistanceIdentification and analysis of residues contained on β → α loops of the dual-substrate (βα)8phosphoribosyl isomerase A specific for its phosphoribosyl anthranilate isomerase activityEntropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase IIIDe Novo Fragment Design for Drug Discovery and Chemical BiologyImproving chemical similarity ensemble approach in target predictionDiscovery, Molecular Mechanisms, and Industrial Applications of Cold-Active EnzymesMotif mediated protein-protein interactions as drug targetsBeauty is in the eye of the beholder: proteins can recognize binding sites of homologous proteins in more than one wayThe Mycobacterium tuberculosis drugome and its polypharmacological implicationsExploring off-targets and off-systems for adverse drug reactions via chemical-protein interactome--clozapine-induced agranulocytosis as a case studyCommon and distant structural characteristics of feruloyl esterase families from Aspergillus oryzaeStructural and functional characterization of a multifunctional alanine-rich peptide analogue from Pleuronectes americanusProbabilistic inference of biochemical reactions in microbial communities from metagenomic sequencesDrug Promiscuity in PDB: Protein Binding Site Similarity Is KeyA comprehensive survey of small-molecule binding pockets in proteinsSubstrate-driven mapping of the degradome by comparison of sequence logosVNP: Interactive Visual Network Pharmacology of Diseases, Targets, and DrugsFurther developments towards a genome-scale metabolic model of yeastPrediction and identification of sequences coding for orphan enzymes using genomic and metagenomic neighboursMetaBioME: a database to explore commercially useful enzymes in metagenomic datasetsAn attempt to construct a (general) mathematical framework to model biological "context-dependence".Teaching foundational topics and scientific skills in biochemistry within the conceptual framework of HIV protease.Molecular signatures-based prediction of enzyme promiscuity.Dynamic New World: Refining Our View of Protein Structure, Function and EvolutionCharacterizing protein domain associations by Small-molecule ligand bindingIngestion-controlling network: what's language got to do with it?Protein pockets: inventory, shape, and comparisonDesigning molecular dynamics simulations to shift populations of the conformational states of calmodulin.Designing allostery-inspired response in mechanical networksThe quest for molecular quasi-species in ligand-activity space and its application to directed enzyme evolution.Exploring functional roles of multibinding protein interfaces.Targeting ligand-gated ion channels in neurology and psychiatry: is pharmacological promiscuity an obstacle or an opportunity?
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Protein promiscuity and its implications for biotechnology.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Protein promiscuity and its implications for biotechnology.
@en
Protein promiscuity and its implications for biotechnology.
@nl
type
label
Protein promiscuity and its implications for biotechnology.
@en
Protein promiscuity and its implications for biotechnology.
@nl
prefLabel
Protein promiscuity and its implications for biotechnology.
@en
Protein promiscuity and its implications for biotechnology.
@nl
P2860
P356
P1433
P1476
Protein promiscuity and its implications for biotechnology.
@en
P2093
Angelo D Favia
P2860
P2888
P304
P356
10.1038/NBT1519
P577
2009-02-01T00:00:00Z