T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event
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Positive evidence for vitamin A role in prevention of type 1 diabetesMemory T Cell MigrationVirus infections in type 1 diabetesGenetics, pathogenesis and clinical interventions in type 1 diabetesType 1 diabetes: translating mechanistic observations into effective clinical outcomesInsulin as a key autoantigen in the development of type 1 diabetesTCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential.In situ recognition of autoantigen as an essential gatekeeper in autoimmune CD8+ T cell inflammationThe central role of antigen presentation in islets of Langerhans in autoimmune diabetesDeficiency in B7-H1 (PD-L1)/PD-1 coinhibition triggers pancreatic beta-cell destruction by insulin-specific, murine CD8 T-cells.Cutting edge: accelerated autoimmune diabetes in the absence of LAG-3Vkappa polymorphisms in NOD mice are spread throughout the entire immunoglobulin kappa locus and are shared by other autoimmune strainsCentral nervous system destruction mediated by glutamic acid decarboxylase-specific CD4+ T cells.Detection of T cell responses to a ubiquitous cellular protein in autoimmune diseaseIslet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice.An update on the use of NOD mice to study autoimmune (Type 1) diabetes.Cellular and molecular events in the localization of diabetogenic T cells to islets of Langerhans.The nonconventional MHC class II molecule DM governs diabetes susceptibility in NOD miceA missing PD-L1/PD-1 coinhibition regulates diabetes induction by preproinsulin-specific CD8 T-cells in an epitope-specific mannerHigh-throughput sequencing of islet-infiltrating memory CD4+ T cells reveals a similar pattern of TCR Vβ usage in prediabetic and diabetic NOD micePopulation dynamics of islet-infiltrating cells in autoimmune diabetes.Autoreactive cytotoxic T lymphocytes acquire higher expression of cytotoxic effector markers in the islets of NOD mice after priming in pancreatic lymph nodesT cell-driven initiation and propagation of autoimmune diabetesAnti-FcεR1 antibody injections activate basophils and mast cells and delay Type 1 diabetes onset in NOD mice.Harnessing memory adaptive regulatory T cells to control autoimmunity in type 1 diabetes.Breakdown in peripheral tolerance in type 1 diabetes in mice and humansFollowing the fate of one insulin-reactive CD4 T cell: conversion into Teffs and Tregs in the periphery controls diabetes in NOD mice.Cumulative autoimmunity: T cell clones recognizing several self-epitopes exhibit enhanced pathogenicityMechanistic basis of immunotherapies for type 1 diabetes mellitusDifferential responses of pancreatic β-cells to ROS and RNS.Pathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease.Comparative genetics: synergizing human and NOD mouse studies for identifying genetic causation of type 1 diabetesHydrophobic CDR3 residues promote the development of self-reactive T cells.Anti-coreceptor therapy drives selective T cell egress by suppressing inflammation-dependent chemotactic cues.Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetesRegulatory T cells directed to the site of the action.Inducing immune tolerance: a focus on Type 1 diabetes mellitus.Exosomes released by islet-derived mesenchymal stem cells trigger autoimmune responses in NOD mice.Genetic and Pharmacologic Models for Type 1 Diabetes.CD4 T cells and their antigens in the pathogenesis of autoimmune diabetes.
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T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 08 October 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
T cell islet accumulation in t ...... gulated, cell-autonomous event
@en
T cell islet accumulation in t ...... ulated, cell-autonomous event.
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type
label
T cell islet accumulation in t ...... gulated, cell-autonomous event
@en
T cell islet accumulation in t ...... ulated, cell-autonomous event.
@nl
prefLabel
T cell islet accumulation in t ...... gulated, cell-autonomous event
@en
T cell islet accumulation in t ...... ulated, cell-autonomous event.
@nl
P2093
P2860
P1433
P1476
T cell islet accumulation in t ...... gulated, cell-autonomous event
@en
P2093
Amanda R Burton
Dario A A Vignali
Erica Vincent
Greig P Lennon
Paula Y Arnold
Pere Santamaria
P2860
P304
P356
10.1016/J.IMMUNI.2009.07.008
P407
P577
2009-10-08T00:00:00Z