PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background.
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The role for protein tyrosine phosphatase non-receptor type 22 in regulating intestinal homeostasisPTPN22 R620W Polymorphism is Associated with Myasthenia Gravis Risk: A Systematic Review and Meta-AnalysisA functional framework for interpretation of genetic associations in T1DThe role of PTPN22 risk variant in the development of autoimmunity: finding common ground between mouse and humanThe autoimmunity risk variant LYP-W620 cooperates with CSK in the regulation of TCR signaling.Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells.LYP inhibits T-cell activation when dissociated from CSK.Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-α receptor signalingThe autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses.Systems biology of lupus: mapping the impact of genomic and environmental factors on gene expression signatures, cellular signaling, metabolic pathways, hormonal and cytokine imbalance, and selecting targets for treatment.Pathogenesis of human systemic lupus erythematosus: recent advances.T-cell and B-cell signaling biomarkers and treatment targets in lupus.CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic developmentLymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases.Recent advances in the genetics of systemic lupus erythematosus.Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?PTPN22.6, a dominant negative isoform of PTPN22 and potential biomarker of rheumatoid arthritis.The effect of the autoimmunity-associated gene, PTPN22, on a BXSB-derived model of lupusSupervised machine learning and logistic regression identifies novel epistatic risk factors with PTPN22 for rheumatoid arthritis.PTPN22: the archetypal non-HLA autoimmunity gene.Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease.Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival.Epidermal growth factor receptor (EGFR)-mediated positive feedback of protein-tyrosine phosphatase epsilon (PTPepsilon) on ERK1/2 and AKT protein pathways is required for survival of human breast cancer cells.Unbiased modifier screen reveals that signal strength determines the regulatory role murine TLR9 plays in autoantibody production.PTPN22 alters the development of regulatory T cells in the thymus.K-RAS GTPase- and B-RAF kinase-mediated T-cell tolerance defects in rheumatoid arthritis.Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT.Endogenous antigen tunes the responsiveness of naive B cells but not T cellsPtpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice.An extracatalytic function of CD45 in B cells is mediated by CD22.Association between PTPN22 C1858T polymorphism and alopecia areata riskNegative regulation of TLR signaling in myeloid cells--implications for autoimmune diseases.GWAS implicates a role for quantitative immune traits and threshold effects in risk for human autoimmune disordersPTPN22 silencing in the NOD model indicates the type 1 diabetes-associated allele is not a loss-of-function variant.The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity.A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.Functional development of the T cell receptor for antigenObstacles and opportunities for targeting the effector T cell response in type 1 diabetes.Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice.Protein tyrosine phosphatases and type 1 diabetes: genetic and functional implications of PTPN2 and PTPN22
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PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background.
description
article científic
@ca
article scientifique
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articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on April 2009
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
PTPN22 deficiency cooperates w ...... n a non-autoimmune background.
@en
PTPN22 deficiency cooperates w ...... n a non-autoimmune background.
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type
label
PTPN22 deficiency cooperates w ...... n a non-autoimmune background.
@en
PTPN22 deficiency cooperates w ...... n a non-autoimmune background.
@nl
prefLabel
PTPN22 deficiency cooperates w ...... n a non-autoimmune background.
@en
PTPN22 deficiency cooperates w ...... n a non-autoimmune background.
@nl
P2093
P2860
P356
P1476
PTPN22 deficiency cooperates w ...... on a non-autoimmune background
@en
P2093
Andrew Chan
David Steiner
Kiminori Hasegawa
Michelle Hermiston
P2860
P304
P356
10.4049/JIMMUNOL.0803317
P407
P577
2009-04-01T00:00:00Z