A systematic analysis of predicted phosphorylation sites within the human pregnane X receptor protein. - Wikidata - awgldk - TriplyDB

A systematic analysis of predicted phosphorylation sites within the human pregnane X receptor protein.

A systematic analysis of predicted phosphorylation sites within the human pregnane X receptor protein.

http://www.wikidata.org/entity/Q37397224

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Pregnane X receptor as a target for treatment of inflammatory bowel disorders A PXR-mediated negative feedback loop attenuates the expression of CYP3A in response to the PXR agonist pregnenalone-16α-carbonitrile Flavonoids activate pregnane x receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells Sulfotransferase genes: regulation by nuclear receptors in response to xeno/endo-biotics.Activation of xenobiotic receptors: driving into the nucleus.A mechanistic insight into 3,4-methylenedioxymethamphetamine ("ecstasy")-mediated hepatotoxicity.Pregnane X receptor is SUMOylated to repress the inflammatory response.Pregnane X receptor and drug-induced liver injury.Site-directed mutagenesis of human cytosolic sulfotransferase (SULT) 2B1b to phospho-mimetic Ser348Asp results in an isoform with increased catalytic activity Serine 350 of human pregnane X receptor is crucial for its heterodimerization with retinoid X receptor alpha and transactivation of target genes in vitro and in vivo Small-molecule modulators of PXR and CAR.SUMOylation and Ubiquitylation Circuitry Controls Pregnane X Receptor Biology in Hepatocytes.Tryptophan 299 is a conserved residue of human pregnane X receptor critical for the functional consequence of ligand binding.Role of CAR and PXR in xenobiotic sensing and metabolism.Identification and characterization of phosphorylation sites within the pregnane X receptor protein.Stability of the human pregnane X receptor is regulated by E3 ligase UBR5 and serine/threonine kinase DYRK2.Nuclear receptor-mediated regulation of carboxylesterase expression and activity.Epigenetic regulation of pregnane X receptor activity.PXR cross-talks with internal and external signals in physiological and pathophysiological responses.Post-translational and post-transcriptional modifications of pregnane X receptor (PXR) in regulation of the cytochrome P450 superfamily.Mechanisms of xenobiotic receptor activation: Direct vs. indirect.A SUMO-acetyl switch in PXR biology.Regulation of PXR and CAR by protein-protein interaction and signaling crosstalk.U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells.The role of residues T248, Y249 and T422 in the function of human pregnane X receptor.Effect of erythropoietin on hepatic cytochrome P450 expression and function in an adenine-fed rat model of chronic kidney disease.A nonradioactive electrophoretic mobility shift assay for measurement of pregnane X receptor binding activity to CYP3A4 response element.Role of c-Jun-N-terminal kinase in pregnane X receptor-mediated induction of human cytochrome P4503A4 in vitro.

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A systematic analysis of predicted phosphorylation sites within the human pregnane X receptor protein.

http://www.wikidata.org/entity/Q37397224

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 17 July 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

A systematic analysis of predi ...... n pregnane X receptor protein.

@en

A systematic analysis of predi ...... n pregnane X receptor protein.

@nl

type

label

A systematic analysis of predi ...... n pregnane X receptor protein.

@en

A systematic analysis of predi ...... n pregnane X receptor protein.

@nl

prefLabel

A systematic analysis of predi ...... n pregnane X receptor protein.

@en

A systematic analysis of predi ...... n pregnane X receptor protein.

@nl

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JPET.109.157180

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Journal of Pharmacology and Experimental Therapeutics

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A systematic analysis of predi ...... n pregnane X receptor protein.

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P2093

Chenshu Xu

http://www.w3.org/2001/XMLSchema#string

Dan Brobst

http://www.w3.org/2001/XMLSchema#string

Jeff L Staudinger

http://www.w3.org/2001/XMLSchema#string

Kristin Lichti-Kaiser

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P2860

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

Comparison of complete nuclear receptor sets from the human, Caenorhabditis elegans and Drosophila genomes

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor.

Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation

Nuclear receptors: integration of multiple signalling pathways through phosphorylation.

The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression.

Overview of the structural basis for transcription regulation by nuclear hormone receptors.

Regulation of drug-metabolizing enzymes and transporters in inflammation.

Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver

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10.1124/JPET.109.157180

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