A systematic analysis of predicted phosphorylation sites within the human pregnane X receptor protein.
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Pregnane X receptor as a target for treatment of inflammatory bowel disordersA PXR-mediated negative feedback loop attenuates the expression of CYP3A in response to the PXR agonist pregnenalone-16α-carbonitrileFlavonoids activate pregnane x receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cellsSulfotransferase genes: regulation by nuclear receptors in response to xeno/endo-biotics.Activation of xenobiotic receptors: driving into the nucleus.A mechanistic insight into 3,4-methylenedioxymethamphetamine ("ecstasy")-mediated hepatotoxicity.Pregnane X receptor is SUMOylated to repress the inflammatory response.Pregnane X receptor and drug-induced liver injury.Site-directed mutagenesis of human cytosolic sulfotransferase (SULT) 2B1b to phospho-mimetic Ser348Asp results in an isoform with increased catalytic activitySerine 350 of human pregnane X receptor is crucial for its heterodimerization with retinoid X receptor alpha and transactivation of target genes in vitro and in vivoSmall-molecule modulators of PXR and CAR.SUMOylation and Ubiquitylation Circuitry Controls Pregnane X Receptor Biology in Hepatocytes.Tryptophan 299 is a conserved residue of human pregnane X receptor critical for the functional consequence of ligand binding.Role of CAR and PXR in xenobiotic sensing and metabolism.Identification and characterization of phosphorylation sites within the pregnane X receptor protein.Stability of the human pregnane X receptor is regulated by E3 ligase UBR5 and serine/threonine kinase DYRK2.Nuclear receptor-mediated regulation of carboxylesterase expression and activity.Epigenetic regulation of pregnane X receptor activity.PXR cross-talks with internal and external signals in physiological and pathophysiological responses.Post-translational and post-transcriptional modifications of pregnane X receptor (PXR) in regulation of the cytochrome P450 superfamily.Mechanisms of xenobiotic receptor activation: Direct vs. indirect.A SUMO-acetyl switch in PXR biology.Regulation of PXR and CAR by protein-protein interaction and signaling crosstalk.U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells.The role of residues T248, Y249 and T422 in the function of human pregnane X receptor.Effect of erythropoietin on hepatic cytochrome P450 expression and function in an adenine-fed rat model of chronic kidney disease.A nonradioactive electrophoretic mobility shift assay for measurement of pregnane X receptor binding activity to CYP3A4 response element.Role of c-Jun-N-terminal kinase in pregnane X receptor-mediated induction of human cytochrome P4503A4 in vitro.
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A systematic analysis of predicted phosphorylation sites within the human pregnane X receptor protein.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 17 July 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
A systematic analysis of predi ...... n pregnane X receptor protein.
@en
A systematic analysis of predi ...... n pregnane X receptor protein.
@nl
type
label
A systematic analysis of predi ...... n pregnane X receptor protein.
@en
A systematic analysis of predi ...... n pregnane X receptor protein.
@nl
prefLabel
A systematic analysis of predi ...... n pregnane X receptor protein.
@en
A systematic analysis of predi ...... n pregnane X receptor protein.
@nl
P2093
P2860
P356
P1476
A systematic analysis of predi ...... n pregnane X receptor protein.
@en
P2093
Chenshu Xu
Dan Brobst
Jeff L Staudinger
Kristin Lichti-Kaiser
P2860
P356
10.1124/JPET.109.157180
P407
P577
2009-07-17T00:00:00Z