The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism. - Wikidata - awgldk - TriplyDB

The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism.

The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism.

http://www.wikidata.org/entity/Q37400616

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Role of pregnane X receptor in chemotherapeutic treatment Is dietary fat, vitamin D, or folate associated with pancreatic cancer?Marine invertebrate xenobiotic-activated nuclear receptors: their application as sensor elements in high-throughput bioassays for marine bioactive compounds Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions Pregnane X receptor knockout mice display aging-dependent wearing of articular cartilage Novel functions of PXR in cardiometabolic disease.A metagenomic β-glucuronidase uncovers a core adaptive function of the human intestinal microbiome.Glucose-dependent regulation of pregnane X receptor is modulated by AMP-activated protein kinase.Sulfotransferase genes: regulation by nuclear receptors in response to xeno/endo-biotics.Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells.Pregnane X receptor suppresses proliferation and tumourigenicity of colon cancer cells.Circulating 25-hydroxyvitamin D and risk of pancreatic cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation.Bisphenol A increases atherosclerosis in pregnane X receptor-humanized ApoE deficient mice.Activation of pregnane X receptor by pregnenolone 16 α-carbonitrile prevents high-fat diet-induced obesity in AKR/J mice.Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR.Pregnane X receptor PXR activates the GADD45beta gene, eliciting the p38 MAPK signal and cell migration.Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CAR B-1 cell lymphoma in mice lacking the steroid and xenobiotic receptor, SXR.Irinotecan induces steroid and xenobiotic receptor (SXR) signaling to detoxification pathway in colon cancer cells.Deficiency of PXR decreases atherosclerosis in apoE-deficient mice.Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently Intestinal pregnane X receptor links xenobiotic exposure and hypercholesterolemia.Pregnane X receptor knockout mice display osteopenia with reduced bone formation and enhanced bone resorption.Bisphenol A and its analogues activate human pregnane X receptor The steroid and xenobiotic receptor negatively regulates B-1 cell development in the fetal liver.Pregnane X Receptor Represses HNF4α Gene to Induce Insulin-Like Growth Factor-Binding Protein IGFBP1 that Alters Morphology of and Migrates HepG2 Cells.Influence of drugs on vitamin D and calcium metabolism Top Three Pharmacogenomics and Personalized Medicine Applications at the Nexus of Renal Pathophysiology and Cardiovascular Medicine.Ginkgolide B protects human umbilical vein endothelial cells against xenobiotic injuries via PXR activation.Pregnane X receptor mediates dyslipidemia induced by the HIV protease inhibitor amprenavir in mice.The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes.Pregnane X Receptor Regulates Pathogen-Induced Inflammation and Host Defense against an Intracellular Bacterial Infection through Toll-like Receptor 4.Activation of PXR induces hypercholesterolemia in wild-type and accelerates atherosclerosis in apoE deficient mice.Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in zebrafish (Danio rerio)Post-translational and post-transcriptional modifications of pregnane X receptor (PXR) in regulation of the cytochrome P450 superfamily.Nutrigenomics and cancer.Acetylation of lysine 109 modulates pregnane X receptor DNA binding and transcriptional activity.Role of pregnane X-receptor in regulating bacterial translocation in chronic liver diseases.Epigenetic impact of endocrine disrupting chemicals on lipid homeostasis and atherosclerosis: a pregnane X receptor-centric view.

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P2860

The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism.

http://www.wikidata.org/entity/Q37400616

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 16 January 2009

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism.

@en

The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism.

@nl

type

label

The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism.

@en

The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism.

@nl

prefLabel

The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism.

@en

The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism.

@nl

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Nuclear Receptor Signaling

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The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism.

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Bruce Blumberg

http://www.w3.org/2001/XMLSchema#string

Changcheng Zhou

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Suman Verma

http://www.w3.org/2001/XMLSchema#string

P2860

Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin

Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia

A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure

Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates

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e001

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scholarly article

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10.1621/NRS.07001

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7

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2009-01-16T00:00:00Z

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24038257

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19240808

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intracellular receptor

transcription factor

polycyclic compound

pharmaceutical preparation

inflammatory bowel diseases

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2646121

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