Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells
about
Microsomal prostaglandin E synthase-1 promotes hepatocarcinogenesis through activation of a novel EGR1/β-catenin signaling axisMultidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseasesPolyunsaturated fatty acid metabolism in prostate cancerSulforaphane inhibits prostaglandin E2 synthesis by suppressing microsomal prostaglandin E synthase 1.Identification of a novel class of anti-inflammatory compounds with anti-tumor activity in colorectal and lung cancers.Identification and development of mPGES-1 inhibitors: where we are at?Cyclooxygenases and lipoxygenases in cancer.Cardiovascular biology of microsomal prostaglandin E synthase-1.Inhibition of 11β-Hydroxysteroid Dehydrogenase Type II Suppresses Lung Carcinogenesis by Blocking Tumor COX-2 Expression as Well as the ERK and mTOR Signaling Pathways.COX/mPGES-1/PGE2 pathway depicts an inflammatory-dependent high-risk neuroblastoma subset.mPGES-1 in prostate cancer controls stemness and amplifies epidermal growth factor receptor-driven oncogenicity.Cyclooxygenase-2, not microsomal prostaglandin E synthase-1, is the mechanism for interleukin-1β-induced prostaglandin E2 production and inhibition of insulin secretion in pancreatic islets.Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling That Drives Tumor Growth, Angiogenesis, and Metastasis.Kruppel-like factor 5 transcription factor promotes microsomal prostaglandin E2 synthase 1 gene transcription in breast cancerGenetic deletion of microsomal prostaglandin E synthase-1 suppresses mouse mammary tumor growth and angiogenesis.Linking microsomal prostaglandin E Synthase-1/PGE-2 pathway with miR-15a and -186 expression: Novel mechanism of VEGF modulation in prostate cancermPGES-1 as a target for cancer suppression: A comprehensive invited review "Phospholipase A2 and lipid mediators".Characterization of microsomal prostaglandin E synthase 1 inhibitors.Diruthenium(ii,iii) metallodrugs of ibuprofen and naproxen encapsulated in intravenously injectable polymer-lipid nanoparticles exhibit enhanced activity against breast and prostate cancer cells.Protective role of humanin on bortezomib-induced bone growth impairment in anticancer treatment.Necrosis in DU145 prostate cancer spheroids induces COX-2/mPGES-1-derived PGE2 to promote tumor growth and to inhibit T cell activation.The therapeutic potential of targeting ABC transporters to combat multi-drug resistance.EGFR signaling upregulates expression of microsomal prostaglandin E synthase-1 in cancer cells leading to enhanced tumorigenicity.Grand challenges in pharmacotherapy of inflammation for the first decades of the 21st century.Structure-based discovery of mPGES-1 inhibitors suitable for preclinical testing in wild-type mice as a new generation of anti-inflammatory drugs.Inhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth.
P2860
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P2860
Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 21 October 2009
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Microsomal prostaglandin E syn ...... prostate and lung cancer cells
@en
Microsomal prostaglandin E syn ...... rostate and lung cancer cells.
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type
label
Microsomal prostaglandin E syn ...... prostate and lung cancer cells
@en
Microsomal prostaglandin E syn ...... rostate and lung cancer cells.
@nl
prefLabel
Microsomal prostaglandin E syn ...... prostate and lung cancer cells
@en
Microsomal prostaglandin E syn ...... rostate and lung cancer cells.
@nl
P2093
P2860
P356
P1476
Microsomal prostaglandin E syn ...... prostate and lung cancer cells
@en
P2093
Agnes Rasmuson
Baldur Sveinbjörnsson
Bengt Samuelsson
Hiromi Hanaka
John Inge Johnsen
Kan Terawaki
Marija Rakonjac
Martin C Schumacher
Mats Hamberg
Per Kogner
P2860
P304
18757-18762
P356
10.1073/PNAS.0910218106
P407
P50
P577
2009-10-21T00:00:00Z