Cocaine esterase prevents cocaine-induced toxicity and the ongoing intravenous self-administration of cocaine in rats.
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Future pharmacological treatments for substance use disordersA Thermally Stable Form of Bacterial Cocaine Esterase: A Potential Therapeutic Agent for Treatment of Cocaine AbuseSubunit Stabilization and Polyethylene Glycolation of Cocaine Esterase Improves In Vivo Residence TimeRational Design, Preparation, and Characterization of a Therapeutic Enzyme Mutant with Improved Stability and Function for Cocaine DetoxificationModeling of pharmacokinetics of cocaine in human reveals the feasibility for development of enzyme therapies for drugs of abuseA thermostable bacterial cocaine esterase rapidly eliminates cocaine from brain in nonhuman primatesDesign of high-activity mutants of human butyrylcholinesterase against (-)-cocaine: structural and energetic factors affecting the catalytic efficiency.Accelerating cocaine metabolism as an approach to the treatment of cocaine abuse and toxicityCombined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion.Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine.Amelioration of the cardiovascular effects of cocaine in rhesus monkeys by a long-acting mutant form of cocaine esterase.Effects of a long-acting mutant bacterial cocaine esterase on acute cocaine toxicity in rats.Enzyme-therapy approaches for the treatment of drug overdose and addiction.The fate of bacterial cocaine esterase (CocE): an in vivo study of CocE-mediated cocaine hydrolysis, CocE pharmacokinetics, and CocE elimination.Bacterial cocaine esterase: a protein-based therapy for cocaine overdose and addictionPharmacokinetic strategies for treatment of drug overdose and addiction.Long-lasting effects of a PEGylated mutant cocaine esterase (CocE) on the reinforcing and discriminative stimulus effects of cocaine in rats.Modification of pharmacokinetic and abuse-related effects of cocaine by human-derived cocaine hydrolase in monkeysCell permeable cocaine esterases constructed by chemical conjugation and genetic recombination.A controlled trial of the adjunct use of D-cycloserine to facilitate cognitive behavioral therapy outcomes in a cocaine-dependent populationRepeated administration of a mutant cocaine esterase: effects on plasma cocaine levels, cocaine-induced cardiovascular activity, and immune responses in rhesus monkeys.Effects of cocaine hydrolase on cocaine self-administration under a PR schedule and during extended access (escalation) in rats.Interception of cocaine by enzyme or antibody delivered with viral gene transfer: a novel strategy for preventing relapse in recovering drug users.Cocaine hydrolase gene therapy for cocaine abuseEpigenetics: a link between addiction and social environment.Free energy profiles of cocaine esterase-cocaine binding process by molecular dynamics and potential of mean force simulations.Cocaine esterase-cocaine binding process and the free energy profiles by molecular dynamics and potential of mean force simulations.Computational design of a thermostable mutant of cocaine esterase via molecular dynamics simulations.Reaction mechanism for cocaine esterase-catalyzed hydrolyses of (+)- and (-)-cocaine: unexpected common rate-determining step.Clinical Potential of an Enzyme-based Novel Therapy for Cocaine Overdose.Electron Microscopic Visualization of Protein Assemblies on Flattened DNA Origami.
P2860
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P2860
Cocaine esterase prevents cocaine-induced toxicity and the ongoing intravenous self-administration of cocaine in rats.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
@tr
scientific article published on 26 August 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Cocaine esterase prevents coca ...... nistration of cocaine in rats.
@en
Cocaine esterase prevents coca ...... nistration of cocaine in rats.
@nl
type
label
Cocaine esterase prevents coca ...... nistration of cocaine in rats.
@en
Cocaine esterase prevents coca ...... nistration of cocaine in rats.
@nl
prefLabel
Cocaine esterase prevents coca ...... nistration of cocaine in rats.
@en
Cocaine esterase prevents coca ...... nistration of cocaine in rats.
@nl
P2093
P2860
P356
P1476
Cocaine esterase prevents coca ...... nistration of cocaine in rats.
@en
P2093
Chang-Guo Zhan
Diwahar Narasimhan
Gregory T Collins
James H Woods
Mei-Chuan Ko
Remy L Brim
Roger K Sunahara
P2860
P304
P356
10.1124/JPET.108.150029
P407
P577
2009-08-26T00:00:00Z