Ikaros regulates Notch target gene expression in developing thymocytes.
about
Role of Ikaros in T-cell acute lymphoblastic leukemiaRegulatory gene network circuits underlying T cell development from multipotent progenitorsNotch target gene deregulation and maintenance of the leukemogenic phenotype do not require RBP-J kappa in Ikaros null mice.Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.Immature single-positive CD8+ thymocytes represent the transition from Notch-dependent to Notch-independent T-cell development.Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis.Aryl hydrocarbon receptor promotes RORγt⁺ group 3 ILCs and controls intestinal immunity and inflammation.Ikaros-Notch axis in host hematopoietic cells regulates experimental graft-versus-host disease.Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor.Self-renewal of the long-term reconstituting subset of hematopoietic stem cells is regulated by Ikaros.GATA-1 utilizes Ikaros and polycomb repressive complex 2 to suppress Hes1 and to promote erythropoiesisIkaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signalingActivated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia.Variations in mRNA and protein levels of Ikaros family members in pediatric T cell acute lymphoblastic leukemia.Cutting Edge: Ikaros null thymocytes mature into the CD4 lineage with reduced TCR signal: A study using CD3{zeta} immunoreceptor tyrosine-based activation motif transgenic mice.Ikaros is a regulator of Il10 expression in CD4+ T cells.Comparative kinetic analyses of gene profiles of naïve CD4+ and CD8+ T cells from young and old animals reveal novel age-related alterations.Developmental gene networks: a triathlon on the course to T cell identity.Cytokines, Transcription Factors, and the Initiation of T-Cell Development.Dynamic chromatin regulation at Notch target genes.Notch Signaling in Development, Tissue Homeostasis, and Disease.Novel TCR-Mediated Mechanisms of Notch Activation and Signaling.Ikaros family transcription factors expression in rat thymus: detection of impaired development.
P2860
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P2860
Ikaros regulates Notch target gene expression in developing thymocytes.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
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2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
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2008年學術文章
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name
Ikaros regulates Notch target gene expression in developing thymocytes.
@en
Ikaros regulates Notch target gene expression in developing thymocytes.
@nl
type
label
Ikaros regulates Notch target gene expression in developing thymocytes.
@en
Ikaros regulates Notch target gene expression in developing thymocytes.
@nl
prefLabel
Ikaros regulates Notch target gene expression in developing thymocytes.
@en
Ikaros regulates Notch target gene expression in developing thymocytes.
@nl
P2860
P1476
Ikaros regulates Notch target gene expression in developing thymocytes.
@en
P2093
Sheila Chari
Susan Winandy
P2860
P304
P356
10.4049/JIMMUNOL.181.9.6265
P407
P577
2008-11-01T00:00:00Z