Critical roles for the TSC-mTOR pathway in β-cell function. - Wikidata - awgldk - TriplyDB

Critical roles for the TSC-mTOR pathway in β-cell function.

Critical roles for the TSC-mTOR pathway in β-cell function.

http://www.wikidata.org/entity/Q37430815

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The required beta cell research for improving treatment of type 2 diabetes Role of AKT/mTORC1 pathway in pancreatic β-cell proliferation Raptor regulates functional maturation of murine beta cells.Phloroglucinol induces apoptosis through the regulation of insulin-like growth factor 1 receptor signaling pathways in human colon cancer HT-29 cells.Persistent hyperinsulinemic hypoglycemia of infancy: constitutive activation of the mTOR pathway with associated exocrine-islet transdifferentiation and therapeutic implications Evaluation of the impact of the cancer therapy everolimus on the central nervous system in mice RIP2-mediated LKB1 deletion causes axon degeneration in the spinal cord and hind-limb paralysis.Modulation of ghrelin O-acyltransferase expression in pancreatic islets.Exposure of mouse embryonic pancreas to metformin enhances the number of pancreatic progenitors Differential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 Cells mTORC1 signaling and regulation of pancreatic β-cell mass.Human β-cell proliferation and intracellular signaling: driving in the dark without a road map.Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced β-cell apoptosis Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy.Adaptive β-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression.Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.mTOR couples cellular nutrient sensing to organismal metabolic homeostasis The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy.SAD-A kinase controls islet β-cell size and function as a mediator of mTORC1 signaling.Defective prolactin signaling impairs pancreatic β-cell development during the perinatal period.Sirolimus therapy in a child with partially diazoxide-responsive hyperinsulinaemic hypoglycaemia.Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes.Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin Receptor Wnt signalling and the control of cellular metabolism.Obesity and nutrient sensing TOR pathway in flies and vertebrates: Functional conservation of genetic mechanisms.The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic β-cell mass: implications in the development of type-2 diabetes.PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis.The mTOR signaling pathway in the brain: focus on epilepsy and epileptogenesis.A molecular rheostat at the interface of cancer and diabetes Evidence for rapamycin toxicity in pancreatic β-cells and a review of the underlying molecular mechanisms.mTOR controls ChREBP transcriptional activity and pancreatic β cell survival under diabetic stress.mTOR Signaling in Growth, Metabolism, and Disease.mTORC1 pathway mediates beta cell compensatory proliferation in 60 % partial-pancreatectomy mice.SAD-A and AMPK kinases: the "yin and yang" regulators of mTORC1 signaling in pancreatic β cells.Augmented β-Cell Function and Mass in Glucocorticoid-Treated Rodents Are Associated with Increased Islet Ir-β /AKT/mTOR and Decreased AMPK/ACC and AS160 Signaling.Growth receptor binding protein 10 inhibits glucose-stimulated insulin release from pancreatic β-cells associated with suppression of the insulin/insulin-like growth factor-1 signalling pathway.Effects of mTOR inhibition on cardiac and adipose tissue pathology and glucose metabolism in rats with metabolic syndrome.Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion.The Molecular Mechanism of Glucagon-Like Peptide-1 Therapy in Alzheimer's Disease, Based on a Mechanistic Target of Rapamycin Pathway.mTORC1 Overactivation as a Key Aging Factor in the Progression to Type 2 Diabetes Mellitus

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Critical roles for the TSC-mTOR pathway in β-cell function.

http://www.wikidata.org/entity/Q37430815

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

@tr

scientific article published on 18 August 2009

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

Critical roles for the TSC-mTOR pathway in β-cell function.

@en

Critical roles for the TSC-mTOR pathway in β-cell function.

@nl

type

label

Critical roles for the TSC-mTOR pathway in β-cell function.

@en

Critical roles for the TSC-mTOR pathway in β-cell function.

@nl

prefLabel

Critical roles for the TSC-mTOR pathway in β-cell function.

@en

Critical roles for the TSC-mTOR pathway in β-cell function.

@nl

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AJPENDO.00262.2009

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American Journal of Physiology - Endocrinology and Metabolism

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Critical roles for the TSC-mTOR pathway in β-cell function.

@en

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Darren Opland

http://www.w3.org/2001/XMLSchema#string

David J Kwiatkowski

http://www.w3.org/2001/XMLSchema#string

Eneida C Villanueva

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Heike Münzberg

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Hiroyuki Mori

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Ken Inoki

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Kun-Liang Guan

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Martin G Myers

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Miro Faouzi

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Tsuneo Ikenoue

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P2860

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

Disruption of IRS-2 causes type 2 diabetes in mice

Upregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemia

Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells

Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes

The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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scholarly article

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10.1152/AJPENDO.00262.2009

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5

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297

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Ormond Macdougald

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2009-08-18T00:00:00Z

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19690069

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2781354

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