Critical roles for the TSC-mTOR pathway in β-cell function.
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The required beta cell research for improving treatment of type 2 diabetesRole of AKT/mTORC1 pathway in pancreatic β-cell proliferationRaptor regulates functional maturation of murine beta cells.Phloroglucinol induces apoptosis through the regulation of insulin-like growth factor 1 receptor signaling pathways in human colon cancer HT-29 cells.Persistent hyperinsulinemic hypoglycemia of infancy: constitutive activation of the mTOR pathway with associated exocrine-islet transdifferentiation and therapeutic implicationsEvaluation of the impact of the cancer therapy everolimus on the central nervous system in miceRIP2-mediated LKB1 deletion causes axon degeneration in the spinal cord and hind-limb paralysis.Modulation of ghrelin O-acyltransferase expression in pancreatic islets.Exposure of mouse embryonic pancreas to metformin enhances the number of pancreatic progenitorsDifferential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 CellsmTORC1 signaling and regulation of pancreatic β-cell mass.Human β-cell proliferation and intracellular signaling: driving in the dark without a road map.Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced β-cell apoptosisDifferential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy.Adaptive β-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression.Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.mTOR couples cellular nutrient sensing to organismal metabolic homeostasisThe G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy.SAD-A kinase controls islet β-cell size and function as a mediator of mTORC1 signaling.Defective prolactin signaling impairs pancreatic β-cell development during the perinatal period.Sirolimus therapy in a child with partially diazoxide-responsive hyperinsulinaemic hypoglycaemia.Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes.Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin ReceptorWnt signalling and the control of cellular metabolism.Obesity and nutrient sensing TOR pathway in flies and vertebrates: Functional conservation of genetic mechanisms.The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic β-cell mass: implications in the development of type-2 diabetes.PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis.The mTOR signaling pathway in the brain: focus on epilepsy and epileptogenesis.A molecular rheostat at the interface of cancer and diabetesEvidence for rapamycin toxicity in pancreatic β-cells and a review of the underlying molecular mechanisms.mTOR controls ChREBP transcriptional activity and pancreatic β cell survival under diabetic stress.mTOR Signaling in Growth, Metabolism, and Disease.mTORC1 pathway mediates beta cell compensatory proliferation in 60 % partial-pancreatectomy mice.SAD-A and AMPK kinases: the "yin and yang" regulators of mTORC1 signaling in pancreatic β cells.Augmented β-Cell Function and Mass in Glucocorticoid-Treated Rodents Are Associated with Increased Islet Ir-β /AKT/mTOR and Decreased AMPK/ACC and AS160 Signaling.Growth receptor binding protein 10 inhibits glucose-stimulated insulin release from pancreatic β-cells associated with suppression of the insulin/insulin-like growth factor-1 signalling pathway.Effects of mTOR inhibition on cardiac and adipose tissue pathology and glucose metabolism in rats with metabolic syndrome.Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion.The Molecular Mechanism of Glucagon-Like Peptide-1 Therapy in Alzheimer's Disease, Based on a Mechanistic Target of Rapamycin Pathway.mTORC1 Overactivation as a Key Aging Factor in the Progression to Type 2 Diabetes Mellitus
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P2860
Critical roles for the TSC-mTOR pathway in β-cell function.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 18 August 2009
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vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Critical roles for the TSC-mTOR pathway in β-cell function.
@en
Critical roles for the TSC-mTOR pathway in β-cell function.
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type
label
Critical roles for the TSC-mTOR pathway in β-cell function.
@en
Critical roles for the TSC-mTOR pathway in β-cell function.
@nl
prefLabel
Critical roles for the TSC-mTOR pathway in β-cell function.
@en
Critical roles for the TSC-mTOR pathway in β-cell function.
@nl
P2093
P2860
P1476
Critical roles for the TSC-mTOR pathway in β-cell function.
@en
P2093
Darren Opland
David J Kwiatkowski
Eneida C Villanueva
Heike Münzberg
Hiroyuki Mori
Kun-Liang Guan
Martin G Myers
Miro Faouzi
Tsuneo Ikenoue
P2860
P304
P356
10.1152/AJPENDO.00262.2009
P577
2009-08-18T00:00:00Z