about
Progressive alterations in the hypothalamic-pituitary-adrenal axis in the R6/2 transgenic mouse model of Huntington's disease.Increased metabolism in the R6/2 mouse model of Huntington's disease.Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets.Triggering necroptosis in cisplatin and IAP antagonist-resistant ovarian carcinoma.Sex differences in the genome-wide DNA methylation pattern and impact on gene expression, microRNA levels and insulin secretion in human pancreatic islets.Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion.Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion.Genome-wide DNA promoter methylation and transcriptome analysis in human adipose tissue unravels novel candidate genes for obesity.Lysine demethylase inhibition protects pancreatic β cells from apoptosis and improves β-cell function.Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetesMutant huntingtin interacts with {beta}-tubulin and disrupts vesicular transport and insulin secretion.The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient beta-cell mass and exocytosis.Hormone-sensitive lipase deficiency in mouse islets abolishes neutral cholesterol ester hydrolase activity but leaves lipolysis, acylglycerides, fat oxidation, and insulin secretion intact.Islet beta-cell area and hormone expression are unaltered in Huntington's disease.The effects of high glucose exposure on global gene expression and DNA methylation in human pancreatic islets.Whole-Genome Bisulfite Sequencing of Human Pancreatic Islets Reveals Novel Differentially Methylated Regions in Type 2 Diabetes Pathogenesis.Ectopic expression of PAX5 promotes maintenance of biphenotypic myeloid progenitors coexpressing myeloid and B-cell lineage-associated genes.HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells.MC1568 improves insulin secretion in islets from type 2 diabetes patients and rescues β-cell dysfunction caused by Hdac7 upregulationGlucolipotoxicity Alters Insulin Secretion via Epigenetic Changes in Human Islets
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Karl Bacos
@ast
Karl Bacos
@en
Karl Bacos
@es
Karl Bacos
@nl
Karl Bacos
@sl
type
label
Karl Bacos
@ast
Karl Bacos
@en
Karl Bacos
@es
Karl Bacos
@nl
Karl Bacos
@sl
prefLabel
Karl Bacos
@ast
Karl Bacos
@en
Karl Bacos
@es
Karl Bacos
@nl
Karl Bacos
@sl
P106
P31
P496
0000-0002-2461-9073