Engineering of a chimeric RB69 DNA polymerase sensitive to drugs targeting the cytomegalovirus enzyme.
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Phosphonoformic Acid Inhibits Viral Replication by Trapping the Closed Form of the DNA PolymeraseIn vitro-selected drug-resistant varicella-zoster virus mutants in the thymidine kinase and DNA polymerase genes yield novel phenotype-genotype associations and highlight differences between antiherpesvirus drugs.Pronounced Inhibition Shift from HIV Reverse Transcriptase to Herpetic DNA Polymerases by Increasing the Flexibility of α-Carboxy Nucleoside Phosphonates.Utility of the bacteriophage RB69 polymerase gp43 as a surrogate enzyme for herpesvirus orthologs.
P2860
Engineering of a chimeric RB69 DNA polymerase sensitive to drugs targeting the cytomegalovirus enzyme.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 21 July 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Engineering of a chimeric RB69 ...... ng the cytomegalovirus enzyme.
@en
Engineering of a chimeric RB69 ...... ng the cytomegalovirus enzyme.
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type
label
Engineering of a chimeric RB69 ...... ng the cytomegalovirus enzyme.
@en
Engineering of a chimeric RB69 ...... ng the cytomegalovirus enzyme.
@nl
prefLabel
Engineering of a chimeric RB69 ...... ng the cytomegalovirus enzyme.
@en
Engineering of a chimeric RB69 ...... ng the cytomegalovirus enzyme.
@nl
P2093
P2860
P356
P1476
Engineering of a chimeric RB69 ...... ng the cytomegalovirus enzyme.
@en
P2093
Aleksandr Obikhod
Egor P Tchesnokov
Matthias Götte
P2860
P304
26439-26446
P356
10.1074/JBC.M109.012500
P407
P577
2009-07-21T00:00:00Z