Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B. - Wikidata - awgldk - TriplyDB

Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B.

Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B.

http://www.wikidata.org/entity/Q37447402

about

Current chemical biology approaches to interrogate protein methyltransferases Chemical and biological tools for the preparation of modified histone proteins Application of the protein semisynthesis strategy to the generation of modified chromatin Non-degradative Ubiquitination of Protein Kinases.The challenge of producing ubiquitinated proteins for structural studies Accelerated chromatin biochemistry using DNA-barcoded nucleosome libraries.Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction.Histones: at the crossroads of peptide and protein chemistry.Synthesis of non-linear protein dimers through a genetically encoded Thiol-ene reaction.Structure-guided DOT1L probe optimization by label-free ligand displacement.Histone H2B ubiquitination and beyond: Regulation of nucleosome stability, chromatin dynamics and the trans-histone H3 methylation.Identification of a functional hotspot on ubiquitin required for stimulation of methyltransferase activity on chromatin.Histone monoubiquitylation position determines specificity and direction of enzymatic cross-talk with histone methyltransferases Dot1L and PRC2.Chemical tagging and customizing of cellular chromatin states using ultrafast trans-splicing inteins Dot1 histone methyltransferases share a distributive mechanism but have highly diverged catalytic properties.Stability of nucleosomes containing homogenously ubiquitylated H2A and H2B prepared using semisynthesis Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation.Unraveling the complexity of ubiquitin signaling The n-SET domain of Set1 regulates H2B ubiquitylation-dependent H3K4 methylation.Ubiquitin and proteasomes in transcription Targeted drug discovery for pediatric leukemia.Chemical Synthesis of Phosphorylated Histone H2A at Tyr57 Reveals Insight into the Inhibition Mode of the SAGA Deubiquitinating Module.Chemical Protein Ubiquitylation with Preservation of the Native Cysteine Residues.Chemical approaches for studying histone modifications.Chromatin as an expansive canvas for chemical biology.Nonenzymatic ubiquitylation.Spreading chromatin into chemical biology.A modified epigenetics toolbox to study histone modifications on the nucleosome core.Chemistry and biology of the ubiquitin signal.Synthetic chromatin approaches to probe the writing and erasing of histone modifications.The upstreams and downstreams of H3K79 methylation by DOT1L.The HDAC inhibitor panobinostat (LBH589) exerts in vivo anti-leukaemic activity against MLL-rearranged acute lymphoblastic leukaemia and involves the RNF20/RNF40/WAC-H2B ubiquitination axis.Chemical and semisynthesis of modified histones.Chemical ubiquitination for decrypting a cellular code.Writing, erasing and reading histone lysine methylations.Biological and Physicochemical Functions of Ubiquitylation Revealed by Synthetic Chemistry Approaches.Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases.Peptide o-aminoanilides as crypto-thioesters for protein chemical synthesis.Modifying the vicinity of the isopeptide bond to reveal differential behavior of ubiquitin chains with interacting proteins: organic chemistry applied to synthetic proteins.Traceless and site-specific ubiquitination of recombinant proteins.

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Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B.

http://www.wikidata.org/entity/Q37447402

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Structure-activity analysis of ...... by ubiquitylated histone H2B.

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Structure-activity analysis of ...... by ubiquitylated histone H2B.

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Structure-activity analysis of ...... by ubiquitylated histone H2B.

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Structure-activity analysis of ...... by ubiquitylated histone H2B.

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Champak Chatterjee

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Kyle P Chiang

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Maja Köhn

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Matthew R Pratt

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Robert K McGinty

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Tom W Muir

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P2860

Crystal structure of the nucleosome core particle at 2.8 A resolution

Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation

The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions

RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells

Combinatorial patterns of histone acetylations and methylations in the human genome

Ulp1-SUMO crystal structure and genetic analysis reveal conserved interactions and a regulatory element essential for cell growth in yeast

Solvent mediated interactions in the structure of the nucleosome core particle at 1.9 a resolution

Structure and catalytic mechanism of a SET domain protein methyltransferase

Solution structure of a CUE-ubiquitin complex reveals a conserved mode of ubiquitin binding

Structure of ubiquitin refined at 1.8 A resolution

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