The recombination signals for adeno-associated virus site-specific integration.
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Circular intermediates of recombinant adeno-associated virus have defined structural characteristics responsible for long-term episomal persistence in muscle tissue.Novel cis-acting replication element in the adeno-associated virus type 2 genome is involved in amplification of integrated rep-cap sequences.Efficient integration of recombinant adeno-associated virus DNA vectors requires a p5-rep sequence in cis.Herpesviruses and chromosomal integrationAdeno-associated virus Rep proteins target DNA sequences to a unique locus in the human genomeAdeno-associated virus: from defective virus to effective vectorRoles of adeno-associated virus Rep protein and human chromosome 19 in site-specific recombinationSite-specific integration of adeno-associated virus involves partial duplication of the target locus.Expression of human herpesvirus 6B rep within infected cells and binding of its gene product to the TATA-binding protein in vitro and in vivo.Adeno-associated virus site-specifically integrates into a muscle-specific DNA regionRole of the adenovirus DNA-binding protein in in vitro adeno-associated virus DNA replication.The Adeno-Associated Virus Genome Packaging Puzzle.DNA structure modulates the oligomerization properties of the AAV initiator protein Rep68.Inhibition of herpes simplex virus type 1 replication by adeno-associated virus rep proteins depends on their combined DNA-binding and ATPase/helicase activities.Integration preferences of wildtype AAV-2 for consensus rep-binding sites at numerous loci in the human genome.Adeno-associated virus (AAV) type 5 Rep protein cleaves a unique terminal resolution site compared with other AAV serotypes.Analysis of the effects of charge cluster mutations in adeno-associated virus Rep68 protein in vitroDevelopment of animal models for adeno-associated virus site-specific integration.Adeno-associated virus vectors and hematologyAdeno-associated viral vectors for gene transfer and gene therapy.Stable secondary structure near the nicking site for adeno-associated virus type 2 Rep proteins on human chromosome 19Infectious clones and vectors derived from adeno-associated virus (AAV) serotypes other than AAV type 2.Site-specific integration of adeno-associated virus into an episome with the target locus via a deletion-substitution mechanismConditional site-specific integration into human chromosome 19 by using a ligand-dependent chimeric adeno-associated virus/Rep protein.A chimeric protein containing the N terminus of the adeno-associated virus Rep protein recognizes its target site in an in vivo assay.Mutational analysis of adeno-associated virus type 2 Rep68 protein endonuclease activity on partially single-stranded substrates.Kinetics of recombinant adeno-associated virus-mediated gene transfer.Nonrandom transduction of recombinant adeno-associated virus vectors in mouse hepatocytes in vivo: cell cycling does not influence hepatocyte transduction.Isolation of recombinant adeno-associated virus vector-cellular DNA junctions from mouse liver.Factors affecting the terminal resolution site endonuclease, helicase, and ATPase activities of adeno-associated virus type 2 Rep proteinsAmino-terminal domain exchange redirects origin-specific interactions of adeno-associated virus rep78 in vitro.Adeno-associated virus (AAV) site-specific recombination does not require a Rep-dependent origin of replication within the AAV terminal repeat.A genetic screen identifies a cellular regulator of adeno-associated virus.Characterization of adeno-associated virus genomes isolated from human tissues.Substitution of adeno-associated virus Rep protein binding and nicking sites with human chromosome 19 sequences.A p5 integration efficiency element mediates Rep-dependent integration into AAVS1 at chromosome 19.Rapid establishment of a HEK 293 cell line expressing FVIII-BDD using AAV site-specific integration plasmids.Chromosomal integration and homologous gene targeting by replication-incompetent vectors based on the autonomous parvovirus minute virus of mice.Structure of adeno-associated virus type 2 Rep40-ADP complex: insight into nucleotide recognition and catalysis by superfamily 3 helicasesHerpes simplex virus type 1/adeno-associated virus hybrid vectors mediate site-specific integration at the adeno-associated virus preintegration site, AAVS1, on human chromosome 19.
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The recombination signals for adeno-associated virus site-specific integration.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
The recombination signals for adeno-associated virus site-specific integration.
@en
The recombination signals for adeno-associated virus site-specific integration.
@nl
type
label
The recombination signals for adeno-associated virus site-specific integration.
@en
The recombination signals for adeno-associated virus site-specific integration.
@nl
prefLabel
The recombination signals for adeno-associated virus site-specific integration.
@en
The recombination signals for adeno-associated virus site-specific integration.
@nl
P2093
P2860
P356
P1476
The recombination signals for adeno-associated virus site-specific integration.
@en
P2093
P2860
P304
P356
10.1073/PNAS.93.15.7966
P407
P577
1996-07-01T00:00:00Z