Chemical interrogation of FOXO3a nuclear translocation identifies potent and selective inhibitors of phosphoinositide 3-kinases - Wikidata - awgldk - TriplyDB

Chemical interrogation of FOXO3a nuclear translocation identifies potent and selective inhibitors of phosphoinositide 3-kinases

Chemical interrogation of FOXO3a nuclear translocation identifies potent and selective inhibitors of phosphoinositide 3-kinases

http://www.wikidata.org/entity/Q37460004

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Discovery of a Novel, Isothiazolonaphthoquinone-Based Small Molecule Activator of FOXO Nuclear-Cytoplasmic Shuttling Vorinostat interferes with the signaling transduction pathway of T-cell receptor and synergizes with phosphoinositide-3 kinase inhibitors in cutaneous T-cell lymphoma.A virtual screen identified C96 as a novel inhibitor of phosphatidylinositol 3-kinase that displays potent preclinical activity against multiple myeloma in vitro and in vivo FOXO1: a potential target for human diseases High-content imaging for automated determination of host-cell infection rate by the intracellular parasite Trypanosoma cruzi.Targeting nucleocytoplasmic transport in cancer therapy MAP17 and SGLT1 protein expression levels as prognostic markers for cervical tumor patient survival.Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes Discovery of 14-3-3 protein-protein interaction inhibitors that sensitize multidrug-resistant cancer cells to doxorubicin and the Akt inhibitor GSK690693.Deciphering the role of forkhead transcription factors in cancer therapy Simultaneous inhibition of pan-phosphatidylinositol-3-kinases and MEK as a potential therapeutic strategy in peripheral T-cell lymphomas.Methylseleninic acid promotes antitumour effects via nuclear FOXO3a translocation through Akt inhibition.A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations.Moving to the core: spatiotemporal analysis of Forkhead box O (FOXO) and nuclear factor-κB (NF-κB) nuclear translocation.Worming our way to novel drug discovery with the Caenorhabditis elegans proteostasis network, stress response and insulin-signaling pathways.The development of high-content screening (HCS) technology and its importance to drug discovery.Large-scale image-based screening and profiling of cellular phenotypes.Empowering Regulatory T Cells in Autoimmunity.A novel cyclometallated Pt(II)-ferrocene complex induces nuclear FOXO3a localization and apoptosis and synergizes with cisplatin to inhibit lung cancer cell proliferation.High-content screening of natural products reveals novel nuclear export inhibitors.Biological characterization of ETP-46321 a selective and efficacious inhibitor of phosphoinositide-3-kinases.FOXO transcription factors at the interface of metabolism and cancer.Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin.FOXO3 and related transcription factors in development, aging, and exceptional longevity.A DAF-16/FoxO3a-dependent longevity signal is initiated by antioxidants.Rapid Renal Regulation of Peroxisome Proliferator-activated Receptor γ Coactivator-1α by Extracellular Signal-Regulated Kinase 1/2 in Physiological and Pathological Conditions.

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Chemical interrogation of FOXO3a nuclear translocation identifies potent and selective inhibitors of phosphoinositide 3-kinases

http://www.wikidata.org/entity/Q37460004

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 18 August 2009

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

@cs

name

Chemical interrogation of FOXO ...... of phosphoinositide 3-kinases

@en

Chemical interrogation of FOXO ...... of phosphoinositide 3-kinases.

@nl

type

label

Chemical interrogation of FOXO ...... of phosphoinositide 3-kinases

@en

Chemical interrogation of FOXO ...... of phosphoinositide 3-kinases.

@nl

prefLabel

Chemical interrogation of FOXO ...... of phosphoinositide 3-kinases

@en

Chemical interrogation of FOXO ...... of phosphoinositide 3-kinases.

@nl

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JBC.M109.038984

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Journal of Biological Chemistry

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Chemical interrogation of FOXO ...... of phosphoinositide 3-kinases

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Beatriz G Serelde

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David Soilán

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Guido Kurz

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James R Bischoff

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Jesus Fominaya

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Milagros Lorenzo

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Paolo Pevarello

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Patricia Alfonso

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Plácido A Ceballos

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Sandra Peregrina

http://www.w3.org/2001/XMLSchema#string

P2860

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

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Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

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28392-28400

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scholarly article

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10.1074/JBC.M109.038984

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P433

41

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284

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Julen Oyarzabal

Antonio Cebriá

Amancio Carnero

Teresa G Granda

Ana-Isabel Hernández

María I Albarrán

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2009-08-18T00:00:00Z

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19690175

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2788888

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