Cell intrinsic and extrinsic factors synergize in mice with haploinsufficiency for Tp53, and two human del(5q) genes, Egr1 and Apc.
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Haploinsufficient tumor suppressor genes.Aberrant overexpression of CD14 on granulocytes sensitizes the innate immune response in mDia1 heterozygous del(5q) MDS.A NOX2/Egr-1/Fyn pathway delineates new targets for TKI-resistant malignanciesHaploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice.Therapy-related myeloid neoplasms: when genetics and environment collide.Loss of Egr1, a human del5q gene, accelerates BCR-ABL driven chronic myelogenous leukemia.Inhibition of WNT signaling in the bone marrow niche prevents the development of MDS in the Apcdel/+ MDS mouse model.
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Cell intrinsic and extrinsic factors synergize in mice with haploinsufficiency for Tp53, and two human del(5q) genes, Egr1 and Apc.
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2013 nî lūn-bûn
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Cell intrinsic and extrinsic f ...... n del(5q) genes, Egr1 and Apc.
@en
Cell intrinsic and extrinsic f ...... n del(5q) genes, Egr1 and Apc.
@nl
type
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Cell intrinsic and extrinsic f ...... n del(5q) genes, Egr1 and Apc.
@en
Cell intrinsic and extrinsic f ...... n del(5q) genes, Egr1 and Apc.
@nl
prefLabel
Cell intrinsic and extrinsic f ...... n del(5q) genes, Egr1 and Apc.
@en
Cell intrinsic and extrinsic f ...... n del(5q) genes, Egr1 and Apc.
@nl
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Cell intrinsic and extrinsic f ...... n del(5q) genes, Egr1 and Apc.
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Angela Stoddart
Anthony A Fernald
Jianghong Wang
John Anastasi
Michelle M Le Beau
Theodore Karrison
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P304
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10.1182/BLOOD-2013-05-506568
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2013-11-21T00:00:00Z