p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal.
about
Harnessing the apoptotic programs in cancer stem-like cellsThe cell biology of disease: Acute promyelocytic leukemia, arsenic, and PML bodiesIt takes two to tango, a dance between the cells of origin and cancer stem cells in the Drosophila larval brainCellular reprogramming in skin cancerBalancing self-renewal against genome preservation in stem cells: How do they manage to have the cake and eat it too?Significance of oncogenes and tumor suppressor genes in AML prognosis.Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell populationRole of tumor suppressor genes in the cancer-associated reprogramming of human induced pluripotent stem cells.Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia.Fusaric Acid immunotoxicity and MAPK activation in normal peripheral blood mononuclear cells and Thp-1 cellsThe genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemiaMolecular targets for selective killing of TRAIL-resistant leukemic cells.PTEN action in leukaemia dictated by the tissue microenvironment.MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia.A p53-Pax2 pathway in kidney development: implications for nephrogenesis.MDM4 overexpressed in acute myeloid leukemia patients with complex karyotype and wild-type TP53The TBC1D15 oncoprotein controls stem cell self-renewal through destabilization of the Numb-p53 complexNew plays in the p53 theater.Recent advances in p53 research and cancer treatmentp53, Stem Cells, and Reprogramming: Tumor Suppression beyond Guarding the Genome.Effect of dedifferentiation on time to mutation acquisition in stem cell-driven cancers.Molecular and functional characteristics of ovarian surface epithelial cells transformed by KrasG12D and loss of Pten in a mouse model in vivo.Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance.Cancer stem cells: impact, heterogeneity, and uncertaintyA unique histone deacetylase inhibitor alters microRNA expression and signal transduction in chemoresistant ovarian cancer cellsHDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 AcetylationLoss of p53 accelerates the complications of myelodysplastic syndrome in a NUP98-HOXD13-driven mouse model.Recent Advances and New Strategies in Targeting Plk1 for Anticancer TherapyThe Role of MicroRNAs in Hematopoietic Stem Cell and Leukemic Stem Cell Function.Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis.Therapeutic targeting of the p53 pathway in cancer stem cells.Prognostic impact and targeting of CRM1 in acute myeloid leukemia.Differential effects on ARF stability by normal versus oncogenic levels of c-Myc expression.Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cellsCell intrinsic and extrinsic factors synergize in mice with haploinsufficiency for Tp53, and two human del(5q) genes, Egr1 and Apc.Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice.The emerging functions of the p53-miRNA network in stem cell biology.Resilient and resourceful: genome maintenance strategies in hematopoietic stem cells.Unravelling mechanisms of p53-mediated tumour suppression.
P2860
Q26801037-67435176-83A6-4824-8E50-177D1BD6CF88Q26853348-1931092F-37FD-44F6-B861-572CC765AA6CQ26864457-7A95C20F-F3D8-446B-8DDC-FDF7041EA0EBQ27027468-AE900E8E-020D-48E6-A077-492BF2EC0354Q28070584-AF93AF21-BD1D-4AD8-BD21-E45ADA874CE6Q30250315-41A4B843-1F70-417B-8E2A-E7274E09AC5EQ33731216-9876B51E-A2FC-403A-8F62-C87847E66DBCQ33752469-61DAEA88-8740-4B55-9FF5-2648B130F2FAQ33779805-D3BB297E-AE65-4E57-9D4A-1E43BD7D5DA3Q33780360-3063E3A4-A792-48AA-887F-7FAFA3E3B63DQ33796552-31E9BAFA-C5EA-4F38-A2E4-50C6A75BB80AQ33891400-174511AF-5907-49F3-B934-8D4DAC2F4B3FQ34196262-A6DD1663-02F0-4EF9-B3A0-523B52E4D1AFQ34386922-A0C511EA-7A4A-42EC-AEF4-FA0008650715Q34416207-03341E27-78EB-4103-9102-859354D61E33Q34535844-7EB47905-D308-434D-8968-224D673CD27DQ34612004-4D290D77-D9FF-4F92-BDDB-8397DFEC991DQ34685830-47C86A56-C694-48E5-A53F-B07E5E102A84Q35099531-DF75ED4E-F902-4E38-868E-A904B1711128Q35103179-94E13659-CE60-4F67-B41D-2613E36A3611Q35112649-C4A8356C-5A7A-42E4-B8B5-D02616085FCDQ35116008-56BF54D7-7348-49F5-87B1-53292EF7EA51Q35116967-FC857E96-CC53-4F85-8C82-327B000BDAA1Q35237394-0C213540-D083-4338-B918-7498FA4CE502Q35857599-D00E6766-1476-4672-8EF7-6AA155474E92Q36129967-89A893EC-AD2A-4160-9E82-80516A93629EQ36259601-28CAB376-A23D-49BE-89E5-E6F618DF22FBQ36318158-03D0CC33-C9EC-452B-B377-9329D75BF64CQ36386336-EAA79F47-46AC-463E-894F-366B06F39546Q36612608-204DD289-B506-4688-A28D-28D958006F57Q36618609-71D05539-45EA-494A-8654-AD076426C39FQ36833275-883BAFDB-9F1B-49A4-A1A2-28470804F9A5Q36850849-A34A69A6-74E4-44FE-912A-59BDE0039FC4Q37344073-80E8D5AC-ABB8-4DF8-A785-AB64C6317A96Q37417024-D0524A68-A8D9-460C-AF59-AE1E203C49F6Q37464115-42736440-0852-4B65-8D10-9A2236F536B2Q37585218-90476964-FC13-4077-89E7-E6BF8AD6D78EQ38009641-9EE62D96-B017-411F-84D3-E26D21DA60EFQ38143364-AB16C97B-5941-4D8F-9AC2-22ED4578ADCBQ38205099-F628545B-7D99-4C11-A944-39F09A075518
P2860
p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal.
@ast
p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal.
@en
type
label
p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal.
@ast
p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal.
@en
prefLabel
p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal.
@ast
p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal.
@en
P2093
P2860
P356
P1433
P1476
p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal.
@en
P2093
Ernesto Diaz-Flores
Kevin Shannon
Laura Lintault
Scott C Kogan
Scott W Lowe
P2860
P304
P356
10.1101/GAD.1940710
P577
2010-07-01T00:00:00Z