Involvement of PKC alpha and G-protein-coupled receptor kinase 2 in agonist-selective desensitization of mu-opioid receptors in mature brain neurons.
about
Co-activation of μ- and δ-opioid receptors elicits tolerance to morphine-induced ventilatory depression via generation of peroxynitriteLow-dose morphine elicits ventilatory excitant and depressant responses in conscious rats: Role of peripheral μ-opioid receptorsAgonist-dependent mu-opioid receptor signaling can lead to heterologous desensitization.The effect of protein kinase C and G protein-coupled receptor kinase inhibition on tolerance induced by mu-opioid agonists of different efficacyActivation of protein kinase C (PKC)α or PKCε as an approach to increase morphine tolerance in respiratory depression and lethal overdoseμ-opioid receptors: correlation of agonist efficacy for signalling with ability to activate internalization.Prolonged hypoxia modulates platelet activating factor receptor-mediated responses by fetal ovine pulmonary vascular smooth muscle cells.Identification of phosphorylation sites in the COOH-terminal tail of the μ-opioid receptorOpioid receptor desensitization: mechanisms and its link to toleranceCellular signalling of non-synonymous single-nucleotide polymorphisms of the human μ-opioid receptor (OPRM1)Functional selectivity and time-dependence of μ-opioid receptor desensitization at nerve terminals in the mouse ventral tegmental areaβ-Arrestin-2 knockout prevents development of cellular μ-opioid receptor tolerance but does not affect opioid-withdrawal-related adaptations in single PAG neurons.Does PKC activation increase the homologous desensitization of μ opioid receptors?Functional selectivity at the μ-opioid receptor: implications for understanding opioid analgesia and tolerance.Mu opioid receptor stimulation activates c-Jun N-terminal kinase 2 by distinct arrestin-dependent and independent mechanisms.Role of G Protein-Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and InternalizationMechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons.Ethanol Reversal of Tolerance to the Respiratory Depressant Effects of MorphineFunctional selectivity of kappa opioid receptor agonists in peripheral sensory neurons.Morphine desensitization and cellular tolerance are distinguished in rat locus ceruleus neurons.Ligand-directed signalling within the opioid receptor family.μ-Opioid receptor desensitization: homologous or heterologous?Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.Ethanol reversal of cellular tolerance to morphine in rat locus coeruleus neuronsAnalgesic tolerance of opioid agonists in mutant mu-opioid receptors expressed in sensory neurons following intrathecal plasmid gene delivery.Role of protein kinase C in functional selectivity for desensitization at the mu-opioid receptor: from pharmacological curiosity to therapeutic potential.Morphine-induced trafficking of a mu-opioid receptor interacting protein in rat locus coeruleus neurons.β-arrestins: regulatory role and therapeutic potential in opioid and cannabinoid receptor-mediated analgesia.The μ-opioid receptor: an electrophysiologist's perspective from the sharp end.Agonist-selective patterns of µ-opioid receptor phosphorylation revealed by phosphosite-specific antibodies.Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptorRecovery from mu-opioid receptor desensitization after chronic treatment with morphine and methadone.Deciphering µ-opioid receptor phosphorylation and dephosphorylation in HEK293 cells.GPCR theme editorial.Effect of chronic ethanol treatment on μ-opioid receptor function, interacting proteins and morphine-induced place preference.Effect of Tamoxifen and Brain-Penetrant Protein Kinase C and c-Jun N-Terminal Kinase Inhibitors on Tolerance to Opioid-Induced Respiratory Depression in Mice.Involvement of neuronal nitric oxide synthase in desensitisation of µ-opioid receptors in the rat locus coeruleus.Desensitization and tolerance of mu opioid receptors on pontine Kolliker-Fuse neurons.Inhibition of β-ARK1 Ameliorates Morphine-induced Tolerance and Hyperalgesia Via Modulating the Activity of Spinal NMDA Receptors.Oxycodone-induced tolerance to respiratory depression: reversal by ethanol, pregabalin and protein kinase C inhibition.
P2860
Q30389382-E0895F6C-933F-4F7F-BFFA-05A6BB3CCF36Q30412681-99BB4ABE-7FF8-4F10-8EC6-3A3D645F36B8Q33708526-FAE03761-706B-4BC8-9124-AD7652081F88Q33714922-05EE17E2-FDAE-4D28-A117-E603A11DC25BQ34121723-AB4E0057-8A13-408A-B27F-27F522CC5609Q34310081-6249BC37-6872-4DAA-9A20-5C8FE556B71EQ34348987-2C7627F2-71FC-47C4-830D-6155AA5F4914Q34482298-486ABB9A-D108-4376-8CA1-902FEE6B36C4Q34729984-7A1B1070-CE00-4C9B-961C-362017A5C2A1Q34939590-C2877FA6-FB60-49E4-B802-416BE53127A9Q34939735-A77AF491-827B-4EE1-A933-475B92EF12C1Q34939769-E7665712-2B00-4847-AE5C-BEA321D25F77Q34939849-2966F30F-1F78-4942-B152-79073F8CA302Q35264421-81FA1621-3477-4FCB-A4FA-569FD864A3E3Q35822876-A35233C9-49DF-4B25-BFC1-B6F2FF5FCE3BQ35897872-480103DA-5F46-4C03-B6D1-3B3F30252C54Q36025329-8F906777-DEE7-420C-B8B3-DBECE39EA0CAQ36174854-D07074E9-72C2-4B5C-83D6-C1F4E6A567D0Q36186182-EE4BAE60-603C-49D6-966A-7E9B1C0AA916Q36335620-586E3ED8-7337-4D28-B968-8D8AFBF2B19DQ36382935-9431B92C-A4DE-4A75-8FB7-7A24B4A90F63Q36481130-BEB8D711-A2D3-4EFE-8F80-60BB5BB14F62Q36591603-3D126FAB-C2F0-4CA5-9BDA-C93042BDFAA5Q37027080-752613B0-7672-432F-8134-6D8032378EFBQ37532600-FA539A4C-86DB-47A9-9FE8-0C4CBEAFF929Q37589704-F2577F3F-C773-4754-838F-72C09EFC296DQ37592198-F93977F4-D43A-4EF8-A486-52BDBB27691FQ38167644-AB687A74-BE87-4530-B89A-069944A0BE54Q38196854-ABB6ECB1-7802-4678-A642-330EFF45C578Q38464958-8863C14A-AA9D-4BCA-9BFA-2E20295AFC9EQ41823097-242A9476-CCC5-470A-A1FB-E3C41481870AQ41891627-9E8EDBFF-7C03-4E67-8A0B-3170EF9A3C38Q42000724-09759396-6703-42AF-B846-B8237A851C3FQ42951309-B6B0D299-F77E-4CFD-8393-1D904C3DF38DQ44338130-284785D8-7872-4209-BD7D-8375F9C7C7DFQ44342944-4B57802A-A4A5-49A1-A9EF-D13E42A61F79Q44345561-7F2C8D18-8DB9-46FC-9513-9C687720DFC3Q44350406-010B4951-A573-42FE-BE1B-4E1CD5E2AF63Q47702437-CD1FD226-FABA-4EC5-B54C-67A1069B6E8CQ54119525-3E33FA0A-3382-4B3E-A308-93B5B7F5C696
P2860
Involvement of PKC alpha and G-protein-coupled receptor kinase 2 in agonist-selective desensitization of mu-opioid receptors in mature brain neurons.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 20 March 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Involvement of PKC alpha and G ...... ptors in mature brain neurons.
@en
Involvement of PKC alpha and G ...... ptors in mature brain neurons.
@nl
type
label
Involvement of PKC alpha and G ...... ptors in mature brain neurons.
@en
Involvement of PKC alpha and G ...... ptors in mature brain neurons.
@nl
prefLabel
Involvement of PKC alpha and G ...... ptors in mature brain neurons.
@en
Involvement of PKC alpha and G ...... ptors in mature brain neurons.
@nl
P2093
P2860
P1476
Involvement of PKC alpha and G ...... eptors in mature brain neurons
@en
P2093
A G Teschemacher
G Henderson
J Llorente
S Oldfield
P2860
P304
P356
10.1111/J.1476-5381.2009.00140.X
P407
P577
2009-03-20T00:00:00Z