Recovery from mu-opioid receptor desensitization after chronic treatment with morphine and methadone.
about
Desensitization of functional µ-opioid receptors increases agonist off-rate.Separate GABA afferents to dopamine neurons mediate acute action of opioids, development of tolerance, and expression of withdrawal.Endocytosis, signaling, and beyondOpioid receptor desensitization: mechanisms and its link to toleranceRecent advances on the δ opioid receptor: from trafficking to function.β-Arrestin-2 knockout prevents development of cellular μ-opioid receptor tolerance but does not affect opioid-withdrawal-related adaptations in single PAG neurons.Functional selectivity at the μ-opioid receptor: implications for understanding opioid analgesia and tolerance.Chronic methadone treatment shows a better cost/benefit ratio than chronic morphine in mice.Desensitization and trafficking of μ-opioid receptors in locus ceruleus neurons: modulation by kinases.Role of G Protein-Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and InternalizationMechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons.Evidence that behavioral phenotypes of morphine in β-arr2-/- mice are due to the unmasking of JNK signaling.Agonist Binding and Desensitization of the μ-Opioid Receptor Is Modulated by Phosphorylation of the C-Terminal Tail Domain.Endomorphin-2: a biased agonist at the μ-opioid receptor.Ethanol Reversal of Tolerance to the Respiratory Depressant Effects of MorphineMorphine desensitization and cellular tolerance are distinguished in rat locus ceruleus neurons.Modulating neuromodulation by receptor membrane traffic in the endocytic pathway.μ-Opioid receptor desensitization: homologous or heterologous?Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.Quantitative encoding of the effect of a partial agonist on individual opioid receptors by multisite phosphorylation and threshold detection.Ethanol reversal of cellular tolerance to morphine in rat locus coeruleus neuronsMethadone Reverses Analgesic Tolerance Induced by Morphine Pretreatment.Analgesic tolerance of opioid agonists in mutant mu-opioid receptors expressed in sensory neurons following intrathecal plasmid gene delivery.Morphine-induced trafficking of a mu-opioid receptor interacting protein in rat locus coeruleus neurons.Ligand bias at the μ-opioid receptor.Efficacy and ligand bias at the μ-opioid receptor.β-arrestins: regulatory role and therapeutic potential in opioid and cannabinoid receptor-mediated analgesia.Role of phospholipase d in g-protein coupled receptor functionRGS9-2 Modulates Responses to Oxycodone in Pain-Free and Chronic Pain States.Nucleus accumbens-specific interventions in RGS9-2 activity modulate responses to morphine.Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptorμ opioid receptor activation hyperpolarizes respiratory-controlling Kölliker-Fuse neurons and suppresses post-inspiratory drive.Opioid-related (ORL1) receptors are enriched in a subpopulation of sensory neurons and prolonged activation produces no functional loss of surface N-type calcium channels.Why do patients stay in opioid maintenance treatment?Desensitization and tolerance of mu opioid receptors on pontine Kolliker-Fuse neurons.Inhibition of β-ARK1 Ameliorates Morphine-induced Tolerance and Hyperalgesia Via Modulating the Activity of Spinal NMDA Receptors.Oxycodone-induced tolerance to respiratory depression: reversal by ethanol, pregabalin and protein kinase C inhibition.Cellular tolerance at the µ-opioid receptor is phosphorylation dependent.
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P2860
Recovery from mu-opioid receptor desensitization after chronic treatment with morphine and methadone.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Recovery from mu-opioid recept ...... t with morphine and methadone.
@en
type
label
Recovery from mu-opioid recept ...... t with morphine and methadone.
@en
prefLabel
Recovery from mu-opioid recept ...... t with morphine and methadone.
@en
P2093
P2860
P1476
Recovery from mu-opioid recept ...... t with morphine and methadone.
@en
P2093
Elaine K Lau
John T Williams
Michael Virk
Nidia Quillinan
P2860
P304
P356
10.1523/JNEUROSCI.4874-10.2011
P407
P577
2011-03-01T00:00:00Z