Potent and orally active small-molecule inhibitors of the MDM2-p53 interaction - Wikidata - awgldk - TriplyDB

Potent and orally active small-molecule inhibitors of the MDM2-p53 interaction

Potent and orally active small-molecule inhibitors of the MDM2-p53 interaction

http://www.wikidata.org/entity/Q37483244

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Druggability Assessment of Allosteric Proteins by Dynamics Simulations in the Presence of Probe Molecules Chemical Variations on the p53 Reactivation Theme Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development Targeting MDM2 for Treatment of Adenoid Cystic Carcinoma.Stereoselective synthesis of spirooxindole amides through nitrile hydrozirconation Endosialin expression in side populations in human sarcoma cell lines.p14ARF post-transcriptional regulation of nuclear cyclin D1 in MCF-7 breast cancer cells: discrimination between a good and bad prognosis?Combining targeted agents with modern radiotherapy in soft tissue sarcomas.MI-219-zinc combination: a new paradigm in MDM2 inhibitor-based therapy Phosphoramidite gold(I)-catalyzed diastereo- and enantioselective synthesis of 3,4-substituted pyrrolidines Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment.Rational design of topographical helix mimics as potent inhibitors of protein-protein interactions.Searching for Dual Inhibitors of the MDM2-p53 and MDMX-p53 Protein-Protein Interaction by a Scaffold-Hopping Approach.Small-molecule MDM2-p53 inhibitors: recent advances.State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.Palladium-catalyzed C3-benzylation of indoles Functional advantages of dynamic protein disorder.A green synthetic approach toward the synthesis of structurally diverse spirooxindole derivative libraries under catalyst-free conditions.Ligand binding mode prediction by docking: mdm2/mdmx inhibitors as a case study SAR405838: A Novel and Potent Inhibitor of the MDM2:p53 Axis for the Treatment of Dedifferentiated Liposarcoma.Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice.Targeting p53-MDM2-MDMX loop for cancer therapy.2-Indolinone a versatile scaffold for treatment of cancer: a patent review (2008-2014).Restoration of p53 using the novel MDM2-p53 antagonist APG115 suppresses dedifferentiated papillary thyroid cancer cells.Coccoquinones A and B, new anthraquinone derivatives produced by Staphylotrichum coccosporum PF1460.Systematic Targeting of Protein-Protein Interactions Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction.Computational analysis of spiro-oxindole inhibitors of the MDM2-p53 interaction: insights and selection of novel inhibitors.Synthesis of spiro[isoindole-1,5'-isoxazolidin]-3(2H)-ones as potential inhibitors of the MDM2-p53 interaction.Spiro-oxindoles as a Promising Class of Small Molecule Inhibitors of p53-MDM2 Interaction Useful in Targeted Cancer Therapy.Design of chemically stable, potent, and efficacious MDM2 inhibitors that exploit the retro-mannich ring-opening-cyclization reaction mechanism in spiro-oxindoles.High specificity in protein recognition by hydrogen-bond-surrogate α-helices: selective inhibition of the p53/MDM2 complex.One-pot synthesis of 2-amino-indole-3-carboxamide and analogous.An Efficient Synthesis of Spiro[indoline-3,9'-xanthene]trione Derivatives Catalyzed by Magnesium Perchlorate.Rapid progression to glioblastoma in a subset of IDH-mutated astrocytomas: a genome-wide analysis.Cerium oxide-catalyzed multicomponent condensation approach to spirooxindoles in water.Synthesis of 1′-tetrazolylmethyl-spiro[pyrrolidine-3,3′-oxindoles] via two coupled one-pot processes Ugi-azide/Pictet–Spengler and oxidative spiro-rearrangement

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P2860

Potent and orally active small-molecule inhibitors of the MDM2-p53 interaction

http://www.wikidata.org/entity/Q37483244

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on December 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Potent and orally active small-molecule inhibitors of the MDM2-p53 interaction

@en

Potent and orally active small-molecule inhibitors of the MDM2-p53 interaction.

@nl

type

label

Potent and orally active small-molecule inhibitors of the MDM2-p53 interaction

@en

Potent and orally active small-molecule inhibitors of the MDM2-p53 interaction.

@nl

prefLabel

Potent and orally active small-molecule inhibitors of the MDM2-p53 interaction

@en

Potent and orally active small-molecule inhibitors of the MDM2-p53 interaction.

@nl

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Journal of Medicinal Chemistry

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Potent and orally active small-molecule inhibitors of the MDM2-p53 interaction

@en

P2093

Dajun Yang

http://www.w3.org/2001/XMLSchema#string

Dongguang Qin

http://www.w3.org/2001/XMLSchema#string

Donna McEachern

http://www.w3.org/2001/XMLSchema#string

Guoping Wang

http://www.w3.org/2001/XMLSchema#string

Jianyong Chen

http://www.w3.org/2001/XMLSchema#string

Ke Ding

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Rebecca Miller

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Sanjeev Shangary

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Sanmao Kang

http://www.w3.org/2001/XMLSchema#string

Shanghai Yu

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P2860

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

p53, the cellular gatekeeper for growth and division

Surfing the p53 network

The p53-mdm-2 autoregulatory feedback loop

Live or let die: the cell's response to p53

Small molecule inhibitors of the MDM2-p53 interaction discovered by ensemble-based receptor models.

Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold.

P304

7970-7973

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scholarly article

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10.1021/JM901400Z

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P433

24

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52

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2009-12-01T00:00:00Z

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40022406

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19928922

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2795799

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