High specificity in protein recognition by hydrogen-bond-surrogate α-helices: selective inhibition of the p53/MDM2 complex.
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Multi-Facial, Non-Peptidic α-Helix MimeticsGetting in shape: controlling peptide bioactivity and bioavailability using conformational constraintsAdding diverse noncanonical backbones to rosetta: enabling peptidomimetic designEvaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 DomainThe paradox of conformational constraint in the design of Cbl(TKB)-binding peptidesModeling of arylamide helix mimetics in the p53 peptide binding site of hDM2 suggests parallel and anti-parallel conformations are both stable.Constraining cyclic peptides to mimic protein structure motifs.Effects of side chains in helix nucleation differ from helix propagation.Plucking the high hanging fruit: a systematic approach for targeting protein-protein interactionsRational design of topographical helix mimics as potent inhibitors of protein-protein interactions.Small-molecule proteomimetic inhibitors of the HIF-1α-p300 protein-protein interaction.Ribosomal Synthesis of Macrocyclic Peptides in Vitro and in Vivo Mediated by Genetically Encoded Aminothiol Unnatural Amino AcidsDesigner macrocyclic organo-peptide hybrids inhibit the interaction between p53 and HDM2/X by accommodating a functional α-helix.An orthosteric inhibitor of the Ras-Sos interaction.End-Capped α-Helices as Modulators of Protein FunctionNucleation effects in peptide foldamersDesign, synthesis and protein-targeting properties of thioether-linked hydrogen bond surrogate helicesReversible α-helix formation controlled by a hydrogen bond surrogateAn optimal hydrogen-bond surrogate for α-helices.Helix-mediated protein--protein interactions as targets for intervention using foldamers.Druggability assessment of protein-protein interfaces.Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.Rational design of an orthosteric regulator of hIAPP aggregation.Exploring the consequences of a representative "disallowed" conformation of Aib on a 3₁₀-helical fold.Synthesis of hydrogen-bond surrogate α-helices as inhibitors of protein-protein interactions.Spontaneous head-to-tail cyclization of unprotected linear peptides with the KAHA ligation.Limiting Assumptions in the Design of Peptidomimetics.Protein Domain Mimics as Modulators of Protein-Protein Interactions.Synthesis of bicyclic organo-peptide hybrids via oxime/intein-mediated macrocyclization followed by disulfide bond formation.Foldamers as Anticancer Therapeutics: Targeting Protein-Protein Interactions and the Cell Membrane.A proline-derived transannular N-cap for nucleation of short α-helical peptides.
P2860
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P2860
High specificity in protein recognition by hydrogen-bond-surrogate α-helices: selective inhibition of the p53/MDM2 complex.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh
2010年學術文章
@zh-hant
name
High specificity in protein re ...... ition of the p53/MDM2 complex.
@en
High specificity in protein re ...... ition of the p53/MDM2 complex.
@nl
type
label
High specificity in protein re ...... ition of the p53/MDM2 complex.
@en
High specificity in protein re ...... ition of the p53/MDM2 complex.
@nl
prefLabel
High specificity in protein re ...... ition of the p53/MDM2 complex.
@en
High specificity in protein re ...... ition of the p53/MDM2 complex.
@nl
P2093
P2860
P356
P1433
P1476
High specificity in protein re ...... ition of the p53/MDM2 complex.
@en
P2093
Indraneel Ghosh
Jason R Porter
Laura K Henchey
Paramjit S Arora
P2860
P304
P356
10.1002/CBIC.201000378
P577
2010-10-01T00:00:00Z