Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide.
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Blockade of islet amyloid polypeptide fibrillation and cytotoxicity by the secretory chaperones 7B2 and proSAASA single mutation in the nonamyloidogenic region of islet amyloid polypeptide greatly reduces toxicityIslet amyloid in type 2 diabetes, and the toxic oligomer hypothesisA feline model of experimentally induced islet amyloidosisThe Rationale for Insulin Therapy in Alzheimer's DiseaseThe Effects of Lipid Membranes, Crowding and Osmolytes on the Aggregation, and Fibrillation Propensity of Human IAPPInflammasomes: mechanism of action, role in disease, and therapeuticsOn the Environmental Factors Affecting the Structural and Cytotoxic Properties of IAPP PeptidesUCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells: evidence of interplay between the ubiquitin/proteasome system and autophagyHeparan sulfate proteoglycans in experimental models of diabetes: a role for perlecan in diabetes complicationsSecondary Structure of Rat and Human Amylin across Force FieldsTetracycline treatment retards the onset and slows the progression of diabetes in human amylin/islet amyloid polypeptide transgenic miceActivation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes.Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory.Membrane Curvature-sensing and Curvature-inducing Activity of Islet Amyloid Polypeptide and Its Implications for Membrane Disruption.Membrane remodeling by amyloidogenic and non-amyloidogenic proteins studied by EPR.Dynamics of beta-cell turnover: evidence for beta-cell turnover and regeneration from sources of beta-cells other than beta-cell replication in the HIP ratAn islet in distress: β cell failure in type 2 diabetes.Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes.Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway.Genetic models for non insulin dependent diabetes mellitus in rodents.Expression of wild-type and mutant S20G hIAPP in physiologic knock-in mouse models fails to induce islet amyloid formation, but induces mild glucose intoleranceDrosophila melanogaster as a model system for studies of islet amyloid polypeptide aggregation.Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes.Fibril structure of human islet amyloid polypeptide.Protein misfolding and disease; protein refolding and therapy.Beta-cell selective K(ATP)-channel activation protects beta-cells and human islets from human islet amyloid polypeptide induced toxicity.Identification of cis- and trans-active factors regulating human islet amyloid polypeptide gene expression in pancreatic beta-cells.β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency.The Mitochondrial Peptidase Pitrilysin Degrades Islet Amyloid Polypeptide in Beta-Cells.Diabetes mellitus and Alzheimer's disease: shared pathology and treatment?Conditional transgenic mouse models: from the basics to genome-wide sets of knockouts and current studies of tissue regeneration.Diabetes and insulin secretion: whither KATP?Human but not rat amylin shares neurotoxic properties with Abeta42 in long-term hippocampal and cortical cultures.Amyloidogenicity and cytotoxicity of islet amyloid polypeptide.Distinct internalization pathways of human amylin monomers and its cytotoxic oligomers in pancreatic cellsAnnexin A5 directly interacts with amyloidogenic proteins and reduces their toxicity.Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications.Glucose- and time-dependence of islet amyloid formation in vitro.Intracellular amyloidogenesis by human islet amyloid polypeptide induces apoptosis in COS-1 cells
P2860
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P2860
Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Spontaneous diabetes mellitus ...... man islet amyloid polypeptide.
@en
Spontaneous diabetes mellitus ...... man islet amyloid polypeptide.
@nl
type
label
Spontaneous diabetes mellitus ...... man islet amyloid polypeptide.
@en
Spontaneous diabetes mellitus ...... man islet amyloid polypeptide.
@nl
prefLabel
Spontaneous diabetes mellitus ...... man islet amyloid polypeptide.
@en
Spontaneous diabetes mellitus ...... man islet amyloid polypeptide.
@nl
P2093
P2860
P356
P1476
Spontaneous diabetes mellitus ...... man islet amyloid polypeptide.
@en
P2093
A J Torchia
D K Kreutter
P C Butler
R T Nelson
W C Soeller
P2860
P304
P356
10.1073/PNAS.93.14.7283
P407
P577
1996-07-01T00:00:00Z