BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number - Wikidata - awgldk - TriplyDB

BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number

BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number

http://www.wikidata.org/entity/Q37515419

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Centrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapy BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II.The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function KIAA0101 interacts with BRCA1 and regulates centrosome number Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis A novel role for BRCA1 in regulating breast cancer cell spreading and motility NEDD1-dependent recruitment of the gamma-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly Global approaches to understanding ubiquitination.A guide for functional analysis of BRCA1 variants of uncertain significance The BRCA1 Breast Cancer Suppressor: Regulation of Transport, Dynamics, and Function at Multiple Subcellular Locations Drugging the addict: non-oncogene addiction as a target for cancer therapy Is there more to BARD1 than BRCA1?BRCA1 and Oxidative Stress BRCA1 targets G2/M cell cycle proteins for ubiquitination and proteasomal degradation BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny Estrogen mediates Aurora-A overexpression, centrosome amplification, chromosomal instability, and breast cancer in female ACI rats Homologs of breast cancer genes in plants BRCA1 foci in normal S-phase nuclei are linked to interphase centromeres and replication of pericentric heterochromatin.The relative efficiency of homology-directed repair has distinct effects on proper anaphase chromosome separation.Genetic analysis of BRCA1 ubiquitin ligase activity and its relationship to breast cancer susceptibility.The UPS: a promising target for breast cancer treatment.BRCA1 represses amphiregulin gene expression.Non-visual arrestins are constitutively associated with the centrosome and regulate centrosome function.Identification of Saccharomyces cerevisiae spindle pole body remodeling factors BRCA1 controls the cell division axis and governs ploidy and phenotype in human mammary cells.BRCA1 haploinsufficiency leads to altered expression of genes involved in cellular proliferation and development.Bcr/Abl interferes with the Fanconi anemia/BRCA pathway: implications in the chromosomal instability of chronic myeloid leukemia cells.E2F activators signal and maintain centrosome amplification in breast cancer cells.Causes and consequences of centrosome abnormalities in cancer.Weighing in on ubiquitin: the expanding role of mass-spectrometry-based proteomics.Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer.Microtubule-associated protein Mdp3 promotes breast cancer growth and metastasis Centrosomal microtubule nucleation activity is inhibited by BRCA1-dependent ubiquitination BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair.Identification of breast tumor mutations in BRCA1 that abolish its function in homologous DNA recombination.BP1, an isoform of DLX4 homeoprotein, negatively regulates BRCA1 in sporadic breast cancer Association of BRCA1 and BRCA2 mutations with survival, chemotherapy sensitivity, and gene mutator phenotype in patients with ovarian cancer Differing clinical impact of BRCA1 and BRCA2 mutations in serous ovarian cancer.DNA double-strand break signaling and human disorders.Weighted frequent gene co-expression network mining to identify genes involved in genome stability.

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BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number

http://www.wikidata.org/entity/Q37515419

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on October 2004

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number

@en

BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number.

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type

label

BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number

@en

BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number.

@nl

prefLabel

BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number

@en

BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number.

@nl

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MCB.24.19.8457-8466.2004

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Molecular and Cellular Biology

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BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number

@en

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Brian P Schlegel

http://www.w3.org/2001/XMLSchema#string

Jeffrey D Parvin

http://www.w3.org/2001/XMLSchema#string

Joshua E Elias

http://www.w3.org/2001/XMLSchema#string

Karen Griffin

http://www.w3.org/2001/XMLSchema#string

Lea M Starita

http://www.w3.org/2001/XMLSchema#string

Satish Sankaran

http://www.w3.org/2001/XMLSchema#string

Yuka Machida

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P2860

Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair

Roles of BRCA1 in centrosome duplication

The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin

BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A

BRCA1 supports XIST RNA concentration on the inactive X chromosome

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

Centrosome amplification drives chromosomal instability in breast tumor development.

Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains

Supramolecular complex formation between Rad6 and proteins of the p53 pathway during DNA damage-induced response

ACF consists of two subunits, Acf1 and ISWI, that function cooperatively in the ATP-dependent catalysis of chromatin assembly

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8457-8466

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scholarly article

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10.1128/MCB.24.19.8457-8466.2004

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19

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24

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2004-10-01T00:00:00Z

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8346397

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15367667

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protein ubiquitination

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516733

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