Localized cytosolic domains of the erythropoietin receptor regulate growth signaling and down-modulate responsiveness to granulocyte-macrophage colony-stimulating factor.
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Truncated erythropoietin receptor causes dominantly inherited benign human erythrocytosisIsolation of interleukin 2-induced immediate-early genesMultiple regions within the cytoplasmic domains of the leukemia inhibitory factor receptor and gp130 cooperate in signal transduction in hepatic and neuronal cellsStoichiometric structure-function analysis of the prolactin receptor signaling domain by receptor chimeras.Dna damage-induced G(1) arrest in hematopoietic cells is overridden following phosphatidylinositol 3-kinase-dependent activation of cyclin-dependent kinase 2Mutational analysis of a critical signaling domain of the human interleukin 4 receptor.Activated Ki-Ras complements erythropoietin signaling in CTLL-2 cells, inducing tyrosine phosphorylation of a 160-kDa protein.Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activationA proliferation switch for genetically modified cells.Mammalian granulocyte-macrophage colony-stimulating factor receptor expressed in primary avian hematopoietic progenitors: lineage-specific regulation of proliferation and differentiationA dominant negative erythropoietin (EPO) receptor inhibits EPO-dependent growth and blocks F-gp55-dependent transformation.Murine pluripotent hematopoietic progenitors constitutively expressing a normal erythropoietin receptor proliferate in response to erythropoietin without preferential erythroid cell differentiation.Inactivation of erythropoietin receptor function by point mutations in a region having homology with other cytokine receptors.Distinct regions of the human granulocyte-colony-stimulating factor receptor cytoplasmic domain are required for proliferation and gene inductionMutations in the WSAWSE and cytosolic domains of the erythropoietin receptor affect signal transduction and ligand binding and internalizationHigh-efficiency identification of genes by functional analysis from a retroviral cDNA expression library.Distinct cytoplasmic regions of the human granulocyte colony-stimulating factor receptor involved in induction of proliferation and maturationIn vitro phosphorylation of the erythropoietin receptor and an associated protein, pp130.Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation.Erythropoietin receptor response circuitsIntegrative signaling by minimal erythropoietin receptor forms and c-Kit.GATA-1 dominantly activates a program of erythroid gene expression in factor-dependent myeloid FDCW2 cells.Mitogen-activated protein kinase plays an essential role in the erythropoietin-dependent proliferation of CTLL-2 cells.GATA-1- and FOG-dependent activation of megakaryocytic alpha IIB gene expression.Mitogenic signaling and inhibition of apoptosis via the erythropoietin receptor Box-1 domain.The box1 domain of the erythropoietin receptor specifies Janus kinase 2 activation and functions mitogenically within an interleukin 2 beta-receptor chimera.Erythropoietin-dependent inhibition of apoptosis is supported by carboxyl-truncated receptor forms and blocked by dominant-negative forms of Jak2.Proline-rich sequence-mediated Jak2 association to the prolactin receptor is required but not sufficient for signal transduction.The action of interleukin-2 receptor subunits defines a new type of signaling mechanism for hematopoietin receptors in hepatic cells and fibroblasts.Distinct downstream signaling mechanism between erythropoietin receptor and interleukin-2 receptor.Epo-induced hemoglobinization of SKT6 cells is mediated by minimal cytoplasmic domains of the Epo or prolactin receptors without modulation of GATA-1 or EKLF.
P2860
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P2860
Localized cytosolic domains of the erythropoietin receptor regulate growth signaling and down-modulate responsiveness to granulocyte-macrophage colony-stimulating factor.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on June 1991
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Localized cytosolic domains of ...... age colony-stimulating factor.
@en
Localized cytosolic domains of ...... age colony-stimulating factor.
@nl
type
label
Localized cytosolic domains of ...... age colony-stimulating factor.
@en
Localized cytosolic domains of ...... age colony-stimulating factor.
@nl
prefLabel
Localized cytosolic domains of ...... age colony-stimulating factor.
@en
Localized cytosolic domains of ...... age colony-stimulating factor.
@nl
P2860
P356
P1476
Localized cytosolic domains of ...... age colony-stimulating factor.
@en
P2093
D E Quelle
D M Wojchowski
P2860
P304
P356
10.1073/PNAS.88.11.4801
P407
P577
1991-06-01T00:00:00Z