Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation
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The distal region and receptor tyrosines of the Epo receptor are non-essential for in vivo erythropoiesisSelf-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3The role of suppressors of cytokine signalling in human neoplasmsTranslational isoforms of FOG1 regulate GATA1-interacting complexesSTAT5 activation is critical for the transformation mediated by myeloproliferative disorder-associated JAK2 V617F mutantStoichiometric structure-function analysis of the prolactin receptor signaling domain by receptor chimeras.Erythroid cells rendered erythropoietin independent by infection with Friend spleen focus-forming virus show constitutive activation of phosphatidylinositol 3-kinase and Akt kinase: involvement of insulin receptor substrate-related adapter proteins.Advances in understanding the pathogenesis of primary familial and congenital polycythaemiaErythroblast transformation by the friend spleen focus-forming virus is associated with a block in erythropoietin-induced STAT1 phosphorylation and DNA binding and correlates with high expression of the hematopoietic phosphatase SHP-1.Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range.Differentiation of embryonic stem cells is induced by GATA factorsErythropoietin modulation of podocalyxin and a proposed erythroblast niche.Erythropoietin-induced erythroid differentiation of the human erythroleukemia cell line TF-1 correlates with impaired STAT5 activationFunctional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation.Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors.Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype.Cytokine signals through STAT3 promote expression of granulocyte secondary granule proteins in 32D cellsOligomerization and scaffolding functions of the erythropoietin receptor cytoplasmic tail.Cytokine signaling through Stat3 activates integrins, promotes adhesion, and induces growth arrest in the myeloid cell line 32D.Erythropoietin receptors that signal through Stat5 or Stat3 support fetal liver and adult erythropoiesis: lack of specificity of stat signals during red blood cell development.Inactivation of G-protein-coupled receptor 48 (Gpr48/Lgr4) impairs definitive erythropoiesis at midgestation through down-regulation of the ATF4 signaling pathway.Biology and significance of the JAK/STAT signalling pathways.The erythropoietin receptor: molecular structure and hematopoietic signaling pathways.Definition of the role of tyrosine residues of the common beta subunit regulating multiple signaling pathways of granulocyte-macrophage colony-stimulating factor receptorIdentification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation.An extra high dose of erythropoietin fails to support the proliferation of erythropoietin dependent cell lines.Role of the JNK/c-Jun/AP-1 signaling pathway in galectin-1-induced T-cell death.Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation.Signal transducers and activators of transcription 5 contributes to erythropoietin-mediated neuroprotection against hippocampal neuronal death after transient global cerebral ischemia.Signals for stress erythropoiesis are integrated via an erythropoietin receptor-phosphotyrosine-343-Stat5 axis.
P2860
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P2860
Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Identification of tyrosine res ...... r crucial for STAT5 activation
@ast
Identification of tyrosine res ...... r crucial for STAT5 activation
@en
type
label
Identification of tyrosine res ...... r crucial for STAT5 activation
@ast
Identification of tyrosine res ...... r crucial for STAT5 activation
@en
prefLabel
Identification of tyrosine res ...... r crucial for STAT5 activation
@ast
Identification of tyrosine res ...... r crucial for STAT5 activation
@en
P2093
P2860
P1433
P1476
Identification of tyrosine res ...... r crucial for STAT5 activation
@en
P2093
Chretien S
Dusanter-Fourt I
Gisselbrecht S
Gouilleux F
P2860
P304
P356
10.1002/J.1460-2075.1996.TB00601.X
P407
P577
1996-05-01T00:00:00Z