Analytical FcRn affinity chromatography for functional characterization of monoclonal antibodies. - Wikidata - awgldk - TriplyDB

Analytical FcRn affinity chromatography for functional characterization of monoclonal antibodies.

Analytical FcRn affinity chromatography for functional characterization of monoclonal antibodies.

http://www.wikidata.org/entity/Q37530217

about

The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy In vitro glycoengineering of IgG1 and its effect on Fc receptor binding and ADCC activity Oxidation in the complementarity-determining regions differentially influences the properties of therapeutic antibodies Impact of SPR biosensor assay configuration on antibody: Neonatal Fc receptor binding data.Investigating the interaction between the neonatal Fc receptor and monoclonal antibody variants by hydrogen/deuterium exchange mass spectrometry Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics.Multi-Angle Effector Function Analysis of Human Monoclonal IgG Glycovariants.Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases.A novel approach to investigate the effect of methionine oxidation on pharmacokinetic properties of therapeutic antibodies.Functional assessment of antibody oxidation by native mass spectrometry.Assessment of chemical modifications of sites in the CDRs of recombinant antibodies: Susceptibility vs. functionality of critical quality attributes.Novel human IgG1 and IgG4 Fc-engineered antibodies with completely abolished immune effector functions.Toward in vitro-to-in vivo translation of monoclonal antibody pharmacokinetics: Application of a neonatal Fc receptor-mediated transcytosis assay to understand the interplaying clearance mechanisms.Pharmacokinetic de-risking tools for selection of monoclonal antibody lead candidates.Target-independent variable region mediated effects on antibody clearance can be FcRn independent.Conformational Destabilization of Immunoglobulin G Increases the Low pH Binding Affinity with the Neonatal Fc Receptor.Enrichment of high affinity subclasses and glycoforms from serum-derived IgG using FcγRs as affinity ligands.A Two-pronged Binding Mechanism of IgG to the Neonatal Fc Receptor Controls Complex Stability and IgG Serum Half-life.Evaluation of an FcRn affinity chromatographic method for IgG1-type antibodies and evaluation of IgG variants.A human endothelial cell-based recycling assay for screening of FcRn targeted molecules.Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics.Assessment of susceptible chemical modification sites of trastuzumab and endogenous human immunoglobulins at physiological conditions

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Analytical FcRn affinity chromatography for functional characterization of monoclonal antibodies.

http://www.wikidata.org/entity/Q37530217

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 29 May 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Analytical FcRn affinity chrom ...... tion of monoclonal antibodies.

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Analytical FcRn affinity chrom ...... tion of monoclonal antibodies.

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type

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Analytical FcRn affinity chrom ...... tion of monoclonal antibodies.

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Analytical FcRn affinity chrom ...... tion of monoclonal antibodies.

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Analytical FcRn affinity chrom ...... tion of monoclonal antibodies.

@en

Analytical FcRn affinity chrom ...... tion of monoclonal antibodies.

@nl

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Monoclonal Antibodies

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Analytical FcRn affinity chrom ...... tion of monoclonal antibodies.

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Apollon Papadimitriou

http://www.w3.org/2001/XMLSchema#string

Felix Fingas

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Georg Drabner

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Hubert Hertenberger

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Jan Olaf Stracke

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Johannes Auer

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Lothar Kling

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Petra Rueger

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Stefan Koch

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Stefan Seeber

http://www.w3.org/2001/XMLSchema#string

P2860

Neonatal Fc receptor mediates internalization of Fc in transfected human endothelial cells

Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent binding

Structural basis of pH-dependent antibody binding by the neonatal Fc receptor

Fcgamma receptors as regulators of immune responses

From sorting endosomes to exocytosis: association of Rab4 and Rab11 GTPases with the Fc receptor, FcRn, during recycling.

Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level.

Effects of receptor dimerization on the interaction between the class I major histocompatibility complex-related Fc receptor and IgG.

Neonatal Fc receptor: from immunity to therapeutics

Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn.

Development trends for human monoclonal antibody therapeutics.

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576-586

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scholarly article

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10.4161/MABS.24981

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4

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5

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2013-05-29T00:00:00Z

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237839826

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23765230

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